Unwinding RNA's Secrets: Advances in the Biology, Physics, and Modeling of Complex RNAs

Overview

Journal Curr Opin Struct Biol

Date 2008 Jun 17

PMID 18555681

Citations 29

Authors

Vincent B Chu

Daniel Herschlag

Affiliations

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Abstract

The rapid development of our understanding of the diverse biological roles fulfilled by non-coding RNA has motivated interest in the basic macromolecular behavior, structure, and function of RNA. We focus on two areas in the behavior of complex RNAs. First, we present advances in the understanding of how RNA folding is accomplished in vivo by presenting a mechanism for the action of DEAD-box proteins. Members of this family are intimately associated with almost all cellular processes involving RNA, mediating RNA structural rearrangements and chaperoning their folding. Next, we focus on advances in understanding, and characterizing the basic biophysical forces that govern the folding of complex RNAs. Ultimately we expect that a confluence and synergy between these approaches will lead to profound understanding of RNA and its biology.

Citing Articles

Advances and Mechanisms of RNA-Ligand Interaction Predictions.

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PMID: 39860045 PMC: 11767038. DOI: 10.3390/life15010104.

Base-pair ambiguity and the kinetics of RNA folding.

Zhou G, Loper J, Geman S BMC Bioinformatics. 2019; 20(1):666.

PMID: 31830902 PMC: 6909616. DOI: 10.1186/s12859-019-3303-6.

Predicting Ion Effects in an RNA Conformational Equilibrium.

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Monte Carlo Tightly Bound Ion Model: Predicting Ion-Binding Properties of RNA with Ion Correlations and Fluctuations.

Sun L, Chen S J Chem Theory Comput. 2016; 12(7):3370-81.

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A DEAD-box RNA helicase promotes thermodynamic equilibration of kinetically trapped RNA structures in vivo.

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