Importance of Diffuse Metal Ion Binding to RNA

Overview

Journal Met Ions Life Sci

Publisher De Gruyter

Specialties Biochemistry
Chemistry

Date 2011 Oct 20

PMID 22010269

Citations 17

Authors

Zhi-Jie Tan

Shi-Jie Chen

Affiliations

Soon will be listed here.

Abstract

RNAs are highly charged polyanionic molecules. RNA structure and function are strongly correlated with the ionic condition of the solution. The primary focus of this article is on the role of diffusive ions in RNA folding. Due to the long-range nature of electrostatic interactions, the diffuse ions can contribute significantly to RNA structural stability and folding kinetics. We present an overview of the experimental findings as well as the theoretical developments on the diffuse ion effects in RNA folding. This review places heavy emphasis on the effect of magnesium ions. Magnesium ions play a highly efficient role in stabilizing RNA tertiary structures and promoting tertiary structural folding. The highly efficient role goes beyond the mean-field effect such as the ionic strength. In addition to the effects of specific ion binding and ion dehydration, ion-ion correlation for the diffuse ions can contribute to the efficient role of the multivalent ions such as the magnesium ions in RNA folding.

Citing Articles

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