Modulation of the Intestinal Flora of Mice by Treatment with Aztreonam and Tigemonam

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1991 May 1

PMID 1854181

Citations 2

Authors

M L van Ogtrop

H F Guiot

H Mattie

E van Strijen

B R Sekh

R Van Furth

Affiliations

Soon will be listed here.

Abstract

Oral and parenteral administration of aztreonam and oral administration of tigemonam to conventional mice caused a decrease in the number of aerobic gram-negative rods in the feces. Oral treatment with high doses of aztreonam (greater than or equal to 25 mg/kg/day) and tigemonam (100 mg/kg/day) adversely influenced colonization resistance, whereas oral treatment with lower doses of the monobactams or parenteral treatment with aztreonam did not.

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