Long-range Regulation of Cytokine Gene Expression

Overview

Journal Curr Opin Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2008 May 20

PMID 18485687

Citations 17

Authors

Emily Rowell

Matthias Merkenschlager

Christopher B Wilson

Affiliations

Soon will be listed here.

Abstract

In metazoans, transcription is regulated by promoters and additional elements, which may be located far from their target gene(s). Moreover, genes (including those encoding cytokines and cytokine receptors) are commonly clustered in the genome, providing the opportunity for the shared, competitive, or sequential use of regulatory elements. New techniques, discussed here, are generating an avalanche of high-resolution genome-wide data through which candidate regulatory elements have been identified in specific cell types (including T cells), their functions inferred, and their physical interactions in three-dimensional space demonstrated. As a result, a nearly comprehensive list of regulatory elements in the Th2 cytokine locus, a growing list of elements in the interferon-gamma gene locus, and maps of their three-dimensional interactions are now available, though much remains to be learned about the molecular mechanisms at play, the dynamics of these interactions, and their functional importance.

Citing Articles

A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification.

Liu C, Nagashima H, Fernando N, Bass V, Gopalakrishnan J, Signorella S Immunity. 2024; 57(5):1005-1018.e7.

PMID: 38697116 PMC: 11108081. DOI: 10.1016/j.immuni.2024.04.007.

Co-localization of clusters of TCR-regulated genes with TAD rearrangements.

Gao G, Li P, Leonard W BMC Genomics. 2023; 24(1):650.

PMID: 37898735 PMC: 10613383. DOI: 10.1186/s12864-023-09693-8.

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.

Liu C, Brandt G, Hoang Q, Naumova N, Lazarevic V, Hwang E Proc Natl Acad Sci U S A. 2016; 113(43):E6572-E6581.

PMID: 27791029 PMC: 5087062. DOI: 10.1073/pnas.1613914113.

Comparative analysis of human and mouse transcriptomes of Th17 cell priming.

Tuomela S, Rautio S, Ahlfors H, Oling V, Salo V, Ullah U Oncotarget. 2016; 7(12):13416-28.

PMID: 26967054 PMC: 4924651. DOI: 10.18632/oncotarget.7963.

Long-Range Transcriptional Control of the Il2 Gene by an Intergenic Enhancer.

Mehra P, Wells A Mol Cell Biol. 2015; 35(22):3880-91.

PMID: 26351138 PMC: 4609740. DOI: 10.1128/MCB.00592-15.

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