White Matter Tract Integrity in Aging and Alzheimer's Disease

Overview

Journal Hum Brain Mapp

Publisher Wiley

Specialty Neurology

Date 2008 Apr 17

PMID 18412132

Citations 112

Authors

Jessica S Damoiseaux

Stephen M Smith

Menno P Witter

Ernesto J Sanz-Arigita

Frederik Barkhof

Philip Scheltens

Cornelis J Stam

Mojtaba Zarei

Serge A R B Rombouts

Affiliations

Soon will be listed here.

Abstract

The pattern of degenerative changes in the brain white matter (WM) in aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD) has been under debate. Methods of image analysis are an important factor affecting the outcomes of various studies. Here we used diffusion tensor imaging (DTI) to obtain fractional anisotropy (FA) measures of the WM in healthy young (n = 8), healthy elderly (n = 22), MCI (n = 8), and AD patients (n = 16). We then applied "tract-based spatial statistics" (TBSS) to study the effects of aging, MCI, and AD on WM integrity. Our results show that changes in WM integrity (that is, decreases in FA) are different between healthy aging and AD: in healthy older subjects compared with healthy young subjects decreased FA was primarily observed in frontal, parietal, and subcortical areas whereas in AD, compared with healthy older subjects, decreased FA was only observed in the left anterior temporal lobe. This different pattern of decreased anatomical connectivity in normal aging and AD suggests that AD is not merely accelerated aging.

Citing Articles

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