Detection and Prevalence Patterns of Group I Coronaviruses in Bats, Northern Germany

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2008 Apr 11

PMID 18400147

Citations 121

Authors

Florian Gloza-Rausch

Anne Ipsen

Antje Seebens

Matthias Gottsche

Marcus Panning

Jan Felix Drexler

Nadine Petersen

Augustina Annan

Klaus Grywna

Marcel Muller

Susanne Pfefferle

Christian Drosten

Affiliations

Soon will be listed here.

Abstract

We tested 315 bats from 7 different bat species in northern Germany for coronaviruses by reverse transcription-PCR. The overall prevalence was 9.8%. There were 4 lineages of group I coronaviruses in association with 4 different species of verspertilionid bats (Myotis dasycneme, M. daubentonii, Pipistrellus nathusii, P. pygmaeus). The lineages formed a monophyletic clade of bat coronaviruses found in northern Germany. The clade of bat coronaviruses have a sister relationship with a clade of Chinese type I coronaviruses that were also associated with the Myotis genus (M. ricketti). Young age and ongoing lactation, but not sex or existing gravidity, correlated significantly with coronavirus detection. The virus is probably maintained on the population level by amplification and transmission in maternity colonies, rather than being maintained in individual bats.

Citing Articles

Detection and Prevalence of Coronaviruses in European Bats: A Systematic Review.

Hemnani M, Gomes da Silva P, Thompson G, Poeta P, Rebelo H, Mesquita J Ecohealth. 2024; 21(2-4):125-140.

PMID: 39580592 PMC: 11649736. DOI: 10.1007/s10393-024-01688-5.

Hibernating vesper bats are a weak source for biomonitoring of coronaviruses.

Goll A, Dutra L, Nowicka J, Sgarabotto E, Venkat V, Apoznanski G One Health. 2024; 18:100733.

PMID: 38694618 PMC: 11061333. DOI: 10.1016/j.onehlt.2024.100733.

Presence of in Tree- and Crevice-Dwelling Bats from Portugal.

Hemnani M, Gomes da Silva P, Thompson G, Poeta P, Rebelo H, Mesquita J Viruses. 2024; 16(3).

PMID: 38543799 PMC: 10976264. DOI: 10.3390/v16030434.

A global-scale dataset of bat viral detection suggests that pregnancy reduces viral shedding.

Eskew E, Olival K, Mazet J, Daszak P bioRxiv. 2024; .

PMID: 38464184 PMC: 10925100. DOI: 10.1101/2024.02.25.581969.

Presence of coronaviruses in the common pipistrelle (P. pipistrellus) and Nathusius´ pipistrelle (P. nathusii) in relation to landscape composition.

Jaramillo Ortiz L, Begeman L, Schillemans M, Kuiken T, de Boer W PLoS One. 2023; 18(11):e0293649.

PMID: 38019737 PMC: 10686486. DOI: 10.1371/journal.pone.0293649.

References

Vijgen L, Lemey P, Keyaerts E, Van Ranst M . Genetic variability of human respiratory coronavirus OC43. J Virol. 2005; 79(5):3223-4. PMC: 548474. DOI: 10.1128/JVI.79.5.3223-3225.2005. View

Dominguez S, OShea T, Oko L, Holmes K . Detection of group 1 coronaviruses in bats in North America. Emerg Infect Dis. 2008; 13(9):1295-300. PMC: 2857301. DOI: 10.3201/eid1309.070491. View

Snijder E, Bredenbeek P, Dobbe J, Thiel V, Ziebuhr J, Poon L . Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. J Mol Biol. 2003; 331(5):991-1004. PMC: 7159028. DOI: 10.1016/s0022-2836(03)00865-9. View

Dong B, Liu W, Fan X, Vijaykrishna D, Tang X, Gao F . Detection of a novel and highly divergent coronavirus from asian leopard cats and Chinese ferret badgers in Southern China. J Virol. 2007; 81(13):6920-6. PMC: 1933311. DOI: 10.1128/JVI.00299-07. View

Pensaert M, de Bouck P . A new coronavirus-like particle associated with diarrhea in swine. Arch Virol. 1978; 58(3):243-7. PMC: 7086830. DOI: 10.1007/BF01317606. View

McIntosh K, BECKER W, Chanock R . Growth in suckling-mouse brain of "IBV-like" viruses from patients with upper respiratory tract disease. Proc Natl Acad Sci U S A. 1967; 58(6):2268-73. PMC: 223830. DOI: 10.1073/pnas.58.6.2268. View

Poon L, Chu D, Chan K, Wong O, Ellis T, Leung Y . Identification of a novel coronavirus in bats. J Virol. 2005; 79(4):2001-9. PMC: 546586. DOI: 10.1128/JVI.79.4.2001-2009.2005. View

Peiris J, Yuen K, Osterhaus A, Stohr K . The severe acute respiratory syndrome. N Engl J Med. 2003; 349(25):2431-41. DOI: 10.1056/NEJMra032498. View

Muller M, Paweska J, Leman P, Drosten C, Grywna K, Kemp A . Coronavirus antibodies in African bat species. Emerg Infect Dis. 2008; 13(9):1367-70. PMC: 2857293. DOI: 10.3201/eid1309.070342. View

10.

Li W, Shi Z, Yu M, Ren W, Smith C, Epstein J . Bats are natural reservoirs of SARS-like coronaviruses. Science. 2005; 310(5748):676-9. DOI: 10.1126/science.1118391. View

11.

Siemers B, Schnitzler H . Echolocation signals reflect niche differentiation in five sympatric congeneric bat species. Nature. 2004; 429(6992):657-61. DOI: 10.1038/nature02547. View

12.

Ksiazek T, Erdman D, Goldsmith C, Zaki S, Peret T, Emery S . A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003; 348(20):1953-66. DOI: 10.1056/NEJMoa030781. View

13.

Woo P, Lau S, Yuen K . Infectious diseases emerging from Chinese wet-markets: zoonotic origins of severe respiratory viral infections. Curr Opin Infect Dis. 2006; 19(5):401-7. PMC: 7141584. DOI: 10.1097/01.qco.0000244043.08264.fc. View

14.

Cavanagh D . Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Arch Virol. 1997; 142(3):629-33. View

15.

Chu D, Poon L, Chan K, Chen H, Guan Y, Yuen K . Coronaviruses in bent-winged bats (Miniopterus spp.). J Gen Virol. 2006; 87(Pt 9):2461-2466. DOI: 10.1099/vir.0.82203-0. View

16.

Woo P, Lau S, Li K, Poon R, Wong B, Tsoi H . Molecular diversity of coronaviruses in bats. Virology. 2006; 351(1):180-7. PMC: 7111821. DOI: 10.1016/j.virol.2006.02.041. View

17.

Drosten C, Gunther S, Preiser W, van der Werf S, Brodt H, Becker S . Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003; 348(20):1967-76. DOI: 10.1056/NEJMoa030747. View

18.

de Souza Luna L, Heiser V, Regamey N, Panning M, Drexler J, Mulangu S . Generic detection of coronaviruses and differentiation at the prototype strain level by reverse transcription-PCR and nonfluorescent low-density microarray. J Clin Microbiol. 2007; 45(3):1049-52. PMC: 1829107. DOI: 10.1128/JCM.02426-06. View

19.

Cui J, Han N, Streicker D, Li G, Tang X, Shi Z . Evolutionary relationships between bat coronaviruses and their hosts. Emerg Infect Dis. 2008; 13(10):1526-32. PMC: 2851503. DOI: 10.3201/eid1310.070448. View

20.

Lau S, Woo P, Li K, Huang Y, Wang M, Lam C . Complete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genome. Virology. 2007; 367(2):428-39. PMC: 7103351. DOI: 10.1016/j.virol.2007.06.009. View