Molecular Diversity of Coronaviruses in Bats

Overview

Journal Virology

Specialty Microbiology

Date 2006 May 2

PMID 16647731

Citations 202

Authors

Patrick C Y Woo

Susanna K P Lau

Kenneth S M Li

Rosana W S Poon

Beatrice H L Wong

Hoi-Wah Tsoi

Bethanie C K Yip

Yi Huang

Kwok-Hung Chan

Kwok-Yung Yuen

Affiliations

Soon will be listed here.

Abstract

The existence of coronaviruses in bats is unknown until the recent discovery of bat-SARS-CoV in Chinese horseshoe bats and a novel group 1 coronavirus in other bat species. Among 309 bats of 13 species captured from 20 different locations in rural areas of Hong Kong over a 16-month period, coronaviruses were amplified from anal swabs of 37 (12%) bats by RT-PCR. Phylogenetic analysis of RNA-dependent-RNA-polymerase (pol) and helicase genes revealed six novel coronaviruses from six different bat species, in addition to the two previously described coronaviruses. Among the six novel coronaviruses, four were group 1 coronaviruses (bat-CoV HKU2 from Chinese horseshoe bat, bat-CoV HKU6 from rickett's big-footed bat, bat-CoV HKU7 from greater bent-winged bat and bat-CoV HKU8 from lesser bent-winged bat) and two were group 2 coronaviruses (bat-CoV HKU4 from lesser bamboo bats and bat-CoV HKU5 from Japanese pipistrelles). An astonishing diversity of coronaviruses was observed in bats.

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