New Binary Polymorphisms Reshape and Increase Resolution of the Human Y Chromosomal Haplogroup Tree

Overview

Journal Genome Res

Specialty Genetics

Date 2008 Apr 4

PMID 18385274

Citations 296

Authors

Tatiana M Karafet

Fernando L Mendez

Monica B Meilerman

Peter A Underhill

Stephen L Zegura

Michael F Hammer

Affiliations

Soon will be listed here.

Abstract

Markers on the non-recombining portion of the human Y chromosome continue to have applications in many fields including evolutionary biology, forensics, medical genetics, and genealogical reconstruction. In 2002, the Y Chromosome Consortium published a single parsimony tree showing the relationships among 153 haplogroups based on 243 binary markers and devised a standardized nomenclature system to name lineages nested within this tree. Here we present an extensively revised Y chromosome tree containing 311 distinct haplogroups, including two new major haplogroups (S and T), and incorporating approximately 600 binary markers. We describe major changes in the topology of the parsimony tree and provide names for new and rearranged lineages within the tree following the rules presented by the Y Chromosome Consortium in 2002. Several changes in the tree topology have important implications for studies of human ancestry. We also present demography-independent age estimates for 11 of the major clades in the new Y chromosome tree.

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