Y-chromosome Evidence of Southern Origin of the East Asian-specific Haplogroup O3-M122

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 2005 Aug 5

PMID 16080116

Citations 70

Authors

Hong Shi

Yong-Li Dong

Bo Wen

Chun-Jie Xiao

Peter A Underhill

Pei-Dong Shen

Ranajit Chakraborty

Li Jin

Bing Su

Affiliations

Soon will be listed here.

Abstract

The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an East Asian-specific Y-chromosome haplogroup (O3-M122) in 2,332 individuals from diverse East Asian populations. Our results indicate that the O3-M122 lineage is dominant in East Asian populations, with an average frequency of 44.3%. The microsatellite data show that the O3-M122 haplotypes in southern East Asia are more diverse than those in northern East Asia, suggesting a southern origin of the O3-M122 mutation. It was estimated that the early northward migration of the O3-M122 lineages in East Asia occurred approximately 25,000-30,000 years ago, consistent with the fossil records of modern humans in East Asia.

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