Genotypic Diversity of Coagulase-negative Staphylococci Causing Endocarditis: a Global Perspective

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2008 Mar 28

PMID 18367572

Citations 24

Authors

Cathy A Petti

Keith E Simmon

Jose M Miro

Bruno Hoen

Francesc Marco

Vivian H Chu

Eugene Athan

Suzana Bukovski

Emilio Bouza

Suzanne Bradley

Vance G Fowler

Efthymia Giannitsioti

David Gordon

Porl Reinbott

Tony Korman

Selwyn Lang

Cristina Garcia-de-la-Maria

Annibale Raglio

Arthur J Morris

Patrick Plesiat

Suzanne Ryan

Thanh Doco-Lecompte

Francesca Tripodi

Riccardo Utili

Dannah Wray

J Jeffrey Federspiel

K Boisson

L Barth Reller

David R Murdoch

Christopher W Woods

Affiliations

Soon will be listed here.

Abstract

Coagulase-negative staphylococci (CNS) are important causes of infective endocarditis (IE), but their microbiological profiles are poorly described. We performed DNA target sequencing and susceptibility testing for 91 patients with definite CNS IE who were identified from the International Collaboration on Endocarditis-Microbiology, a large, multicenter, multinational consortium. A hierarchy of gene sequences demonstrated great genetic diversity within CNS from patients with definite endocarditis that represented diverse geographic regions. In particular, rpoB sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance.

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