Tolerance to the Glycopeptides Vancomycin and Teicoplanin in Coagulase-negative Staphylococci

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2006 Nov 23

PMID 17116684

Citations 12

Authors

Ingrid Bourgeois

Martine Pestel-Caron

Jean-Francois Lemeland

Jean-Louis Pons

Francois Caron

Affiliations

Soon will be listed here.

Abstract

Tolerance to vancomycin and teicoplanin in 90 clinical isolates of coagulase-negative staphylococci (CoNS) was investigated by time-kill curve methodology. Only six strains, belonging to the Staphylococcus lugdunensis species, exhibited tolerance. The seven other S. lugdunensis strains tested displayed weak susceptibility to the bactericidal activity of glycopeptides compared to the other CoNS. These phenomena are of concern, since S. lugdunensis is recognized as one of the most pathogenic CoNS.

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