Activities of Daptomycin and Comparative Antimicrobials, Singly and in Combination, Against Extracellular and Intracellular Staphylococcus Aureus and Its Stable Small-colony Variant in Human Monocyte-derived Macrophages and in Broth

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2008 Mar 12

PMID 18332172

Citations 12

Authors

Aldona L Baltch

William J Ritz

Lawrence H Bopp

Phyllis Michelsen

Raymond P Smith

Affiliations

Soon will be listed here.

Abstract

We investigated the antistaphylococcal activities of daptomycin, gentamicin, and rifampin against two Staphylococcus aureus strains and their stable small-colony variants, singly and in combination, in human monocyte-derived macrophages and in broth. Intracellularly, the three-drug combination and two-drug combinations with rifampin were most effective. Extracellularly, daptomycin, daptomycin plus gentamicin, gentamicin plus rifampin, and the three-drug combination had similar activities.

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