Assessment of Echinococcus Granulosus Polymorphism in Qinghai Province, People's Republic of China

Overview

Journal Parasitol Res

Specialty Parasitology

Date 2008 Mar 1

PMID 18309521

Citations 13

Authors

S M Ma

S Maillard

H L Zhao

X Huang

H Wang

P L Geng

J-M Bart

R Piarroux

Affiliations

Soon will be listed here.

Abstract

Cystic echinococcosis (CE) is highly endemic in the Chinese province of Qinghai, located on the Tibetan Plateau. The Echinococcus granulosus sheep strain has already been reported in this focus. To improve our understanding of the role the parasite plays in the high prevalence observed in humans, we assessed the genetic polymorphism of 55 E. granulosus samples (37 from humans) using three discriminative mitochondrial markers: coxI, nadI and atp6. We obtained a total of 13 distinct genotypes which were all related to the common sheep G1 strain. Six of these genotypes have already been reported in China and other foci around the world. The remaining seven genotypes were new variants of the strain. The parasite population which was studied in the present work did not differ substantially from those observed in other foci of CE. Environmental conditions and human behaviour could explain the high incidence of the parasitic disease, particularly in the Tibetan population in the south of Qinghai, most of whom are livestock farmers.

Citing Articles

Update on the genetic diversity and population structure of Echinococcus granulosus in Gansu Province, Tibet Autonomous Region, and Xinjiang Uygur Autonomous Region, Western China, inferred from mitochondrial cox1, nad1, and nad5 sequences.

Shumuye N, Li L, Ohiolei J, Qurishi S, Li W, Zhang N Parasitol Res. 2023; 122(5):1107-1126.

PMID: 36933066 DOI: 10.1007/s00436-023-07811-9.

Sequence analysis of mitochondrial cytochrome c oxidase 1 and cytochrome b genes of echinococcus multilocularis from human patients.

Abulizi A, Wen H, Zhang C, Li L, Ran B, Jiang T Int J Clin Exp Pathol. 2020; 11(2):795-801.

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Genetic variation of Echinococcus spp. in yaks and sheep in the Tibet Autonomous Region of China based on mitochondrial DNA.

Ohiolei J, Xia C, Li L, Liu J, Tang W, Wu Y Parasit Vectors. 2019; 12(1):608.

PMID: 31881922 PMC: 6935104. DOI: 10.1186/s13071-019-3857-1.

Genetic characterization of isolates from various intermediate hosts in the Qinghai-Tibetan Plateau Area, China.

Han X, Jian Y, Zhang X, Ma L, Zhu W, Cai Q Parasitology. 2019; 146(10):1305-1312.

PMID: 31148526 PMC: 6700708. DOI: 10.1017/S0031182019000544.

Mitochondrial genome data confirm that yaks can serve as the intermediate host of Echinococcus canadensis (G10) on the Tibetan Plateau.

Wu Y, Li L, Zhu G, Li W, Zhang N, Li S Parasit Vectors. 2018; 11(1):166.

PMID: 29523164 PMC: 5845295. DOI: 10.1186/s13071-018-2684-0.

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