Biological Augmentation of Rotator Cuff Tendon Repair

Overview

Journal Clin Orthop Relat Res

Publisher Wolters Kluwer

Specialty Orthopedics

Date 2008 Feb 12

PMID 18264850

Citations 79

Authors

David Kovacevic

Scott A Rodeo

Affiliations

Soon will be listed here.

Abstract

A histologically normal insertion site does not regenerate following rotator cuff tendon-to-bone repair, which is likely due to abnormal or insufficient gene expression and/or cell differentiation at the repair site. Techniques to manipulate the biologic events following tendon repair may improve healing. We used a sheep infraspinatus repair model to evaluate the effect of osteoinductive growth factors and BMP-12 on tendon-to-bone healing. Magnetic resonance imaging and histology showed increased formation of new bone and fibrocartilage at the healing tendon attachment site in the treated animals, and biomechanical testing showed improved load-to-failure. Other techniques with potential to augment repair site biology include use of platelets isolated from autologous blood to deliver growth factors to a tendon repair site. Modalities that improve local vascularity, such as pulsed ultrasound, have the potential to augment rotator cuff healing. Important information about the biology of tendon healing can also be gained from studies of substances that inhibit healing, such as nicotine and antiinflammatory medications. Future approaches may include the use of stem cells and transcription factors to induce formation of the native tendon-bone insertion site after rotator cuff repair surgery.

Citing Articles

Collagen Injections for Rotator Cuff Diseases: A Systematic Review.

Aicale R, Savarese E, Mottola R, Corrado B, Sirico F, Pellegrino R Clin Pract. 2025; 15(2).

PMID: 39996698 PMC: 11854470. DOI: 10.3390/clinpract15020028.

Erroneous Differentiation of Tendon Stem/Progenitor Cells in the Pathogenesis of Tendinopathy: Current Evidence and Future Perspectives.

Gao Y, Wang H, Shi L, Lu P, Dai G, Zhang M Stem Cell Rev Rep. 2024; 21(2):423-453.

PMID: 39579294 DOI: 10.1007/s12015-024-10826-z.

Challenges in tendon-bone healing: emphasizing inflammatory modulation mechanisms and treatment.

Jiang F, Zhao H, Zhang P, Bi Y, Zhang H, Sun S Front Endocrinol (Lausanne). 2024; 15:1485876.

PMID: 39568806 PMC: 11576169. DOI: 10.3389/fendo.2024.1485876.

Structure, ingredient, and function-based biomimetic scaffolds for accelerated healing of tendon-bone interface.

Dong Y, Li J, Jiang Q, He S, Wang B, Yi Q J Orthop Translat. 2024; 48:70-88.

PMID: 39185339 PMC: 11342074. DOI: 10.1016/j.jot.2024.07.007.

Arthroscopic cuff repair: footprint remnant preserving versus debriding rotator cuff repair of transtendinous rotator cuff tears with remnant cuff.

Lee J, Ji J, Park S, Suh D, Song K BMC Musculoskelet Disord. 2024; 25(1):302.

PMID: 38632573 PMC: 11022446. DOI: 10.1186/s12891-024-07431-z.

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