Biomimetic Strategies for Tendon/ligament-to-bone Interface Regeneration

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2021 Mar 5

PMID 33665493

Citations 36

Authors

Tingyun Lei

Tao Zhang

Wei Ju

Xiao Chen

Boon Chin Heng

Weiliang Shen

Zi Yin

Affiliations

Soon will be listed here.

Abstract

Tendon/ligament-to-bone healing poses a formidable clinical challenge due to the complex structure, composition, cell population and mechanics of the interface. With rapid advances in tissue engineering, a variety of strategies including advanced biomaterials, bioactive growth factors and multiple stem cell lineages have been developed to facilitate the healing of this tissue interface. Given the important role of structure-function relationship, the review begins with a brief description of enthesis structure and composition. Next, the biomimetic biomaterials including decellularized extracellular matrix scaffolds and synthetic-/natural-origin scaffolds are critically examined. Then, the key roles of the combination, concentration and location of various growth factors in biomimetic application are emphasized. After that, the various stem cell sources and culture systems are described. At last, we discuss unmet needs and existing challenges in the ideal strategies for tendon/ligament-to-bone regeneration and highlight emerging strategies in the field.

Citing Articles

Artificial Single-Layer, Multi-Layer, and Gradient Scaffolds for Enhancing the Healing of Tendon-to-Bone Interfaces: A Mini-Review.

Song T, Guo L, Wang C, Li M Orthop Res Rev. 2025; 17:105-113.

PMID: 40065844 PMC: 11892362. DOI: 10.2147/ORR.S501260.

Advances and challenges in biomaterials for tendon and enthesis repair.

Zhou H, Chen Y, Yan W, Chen X, Zi Y Bioact Mater. 2025; 47:531-545.

PMID: 40062342 PMC: 11889517. DOI: 10.1016/j.bioactmat.2025.01.001.

Development of a Novel Hybprinter-SAM for Functionally Graded Tissue Engineering Constructs with Patterned and Localized Biochemical Signals.

Yang Y, Li J, Kim C, Alizadeh H, Alizadeh H, Garg S Res Sq. 2025; .

PMID: 39975888 PMC: 11838729. DOI: 10.21203/rs.3.rs-5898561/v1.

Tissue Mimetic Membranes for Healing Augmentation of Tendon-Bone Interface in Rotator Cuff Repair.

Zhu Y, Dai B, Zhang S, Liu J, Xu S, Liu W Adv Mater. 2025; 37(10):e2407358.

PMID: 39888084 PMC: 11899491. DOI: 10.1002/adma.202407358.

Hierarchy Reproduction: Multiphasic Strategies for Tendon/Ligament-Bone Junction Repair.

Chen K, Liu Z, Zhou X, Zheng W, Cao H, Yang Z Biomater Res. 2025; 29():0132.

PMID: 39844867 PMC: 11751208. DOI: 10.34133/bmr.0132.

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