Tumor Necrosis Factor-alpha Enhances DMSO-induced Differentiation of HL-60 Cells Through the Activation of ERK/MAPK Pathway

Overview

Journal Int J Hematol

Specialty Hematology

Date 2008 Feb 8

PMID 18256785

Citations 13

Authors

Hong-Nu Yu

Young-Rae Lee

Eun-Mi Noh

Kyung-Sun Lee

Eun-Kyung Song

Myung-Kwan Han

Yong-Chul Lee

Chang-Yeol Yim

Jinny Park

Byeong-Soo Kim

Sung-Ho Lee

Seung Jin Lee

Jong-Suk Kim

Affiliations

Soon will be listed here.

Abstract

The differentiation of promyelocytic leukemic cells into mature cells is the major strategy for drug-based treatment of leukemia. Higher efficient methods to differentiate promyelocytic leukemic cells have been developed using various differentiation inducers including interferon-alpha, interleukin-4, tumor necrosis factor-alpha (TNF-alpha), and dimethyl sulfoxide (DMSO) as a single agent or in combination with each other. Here, we show that a combination of TNF-alpha with DMSO shows a synergic effect on HL-60 cell differentiation through the activation of ERK pathway. TNF-alpha enhanced CD11b expression and percent of cell population in the G1 phase induced by DMSO, which are hallmarks for HL-60 cell differentiation. Inhibition of ERK pathway abolished the synergic effect of TNF-alpha in combination with DMSO on HL-60 differentiation, but the inhibition NF-kappaB pathway did not. These results suggest that TNF-alpha synergistically increases DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK-signaling pathway.

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