Acinetobacter Radioresistens As a Silent Source of Carbapenem Resistance for Acinetobacter Spp

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2008 Jan 16

PMID 18195058

Citations 92

Authors

Laurent Poirel

Samy Figueiredo

Vincent Cattoir

Alessandra Carattoli

Patrice Nordmann

Affiliations

Soon will be listed here.

Abstract

Carbapenem resistance results mostly from the expression of acquired carbapenem-hydrolyzing oxacillinases in Acinetobacter baumannii. The bla OXA-23 oxacillinase gene is increasingly reported worldwide and may represent an emerging threat. Our goal was to identify the progenitor of that carbapenemase gene. A collection of 50 Acinetobacter sp. strains corresponding to several Acinetobacter species was screened for bla(OXA-23)-like genes by PCR and hybridization techniques. Five Acinetobacter radioresistens isolates that were susceptible to carbapenems harbored chromosomally encoded bla OXA-23-like genes. A similar plasmid backbone was identified in several bla OXA-23-positive A. baumannii and A. radioresistens isolates, further strengthening the vectors of exchanges for these bla OXA-23-like genes. Therefore, A. radioresistens, a commensal bacterial species which is identified on the skin of hospitalized and healthy patients (a property shared with A. baumannii), was identified as the source of the bla OXA-23 gene.

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