Members of the MiRNA-200 Family Regulate Olfactory Neurogenesis

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2008 Jan 11

PMID 18184563

Citations 130

Authors

Philip S Choi

Lisa Zakhary

Wen-Yee Choi

Sophie Caron

Ezequiel Alvarez-Saavedra

Eric A Miska

Mike McManus

Brian Harfe

Antonio J Giraldez

H Robert Horvitz

Alexander F Schier

Catherine Dulac

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for terminal differentiation of olfactory precursors in both mouse and zebrafish but are dispensable for proper function of mature olfactory neurons. The repertoire of miRNAs expressed in olfactory tissues contains over 100 distinct miRNAs. A subset, including the miR-200 family, shows high olfactory enrichment and expression patterns consistent with a role during olfactory neurogenesis. Loss of function of the miR-200 family phenocopies the terminal differentiation defect observed in absence of all miRNA activity in olfactory progenitors. Our data support the notion that vertebrate tissue differentiation is controlled by conserved subsets of organ-specific miRNAs in both mouse and zebrafish and provide insights into control mechanisms underlying olfactory differentiation in vertebrates.

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References

Holbrook E, Szumowski K, Schwob J . An immunochemical, ultrastructural, and developmental characterization of the horizontal basal cells of rat olfactory epithelium. J Comp Neurol. 1995; 363(1):129-46. DOI: 10.1002/cne.903630111. View

Sullivan S, Bohm S, Ressler K, Horowitz L, Buck L . Target-independent pattern specification in the olfactory epithelium. Neuron. 1995; 15(4):779-89. DOI: 10.1016/0896-6273(95)90170-1. View

Schier A, Neuhauss S, Helde K, Talbot W, Driever W . The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail. Development. 1997; 124(2):327-42. DOI: 10.1242/dev.124.2.327. View

Cau E, Gradwohl G, Fode C, Guillemot F . Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. Development. 1997; 124(8):1611-21. DOI: 10.1242/dev.124.8.1611. View

Thelu J, Viallet J, Dhouailly D . Differential expression pattern of the three Fringe genes is associated with epidermal differentiation. J Invest Dermatol. 1998; 111(5):903-6. DOI: 10.1046/j.1523-1747.1998.00372.x. View

Malnic B, Hirono J, Sato T, Buck L . Combinatorial receptor codes for odors. Cell. 1999; 96(5):713-23. DOI: 10.1016/s0092-8674(00)80581-4. View

Belluscio L, Koentges G, Axel R, Dulac C . A map of pheromone receptor activation in the mammalian brain. Cell. 1999; 97(2):209-20. DOI: 10.1016/s0092-8674(00)80731-x. View

Vasioukhin V, Degenstein L, Wise B, Fuchs E . The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A. 1999; 96(15):8551-6. PMC: 17554. DOI: 10.1073/pnas.96.15.8551. View

Botchkarev V, Sharov A . BMP signaling in the control of skin development and hair follicle growth. Differentiation. 2004; 72(9-10):512-26. DOI: 10.1111/j.1432-0436.2004.07209005.x. View

10.

Lewis B, Burge C, Bartel D . Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005; 120(1):15-20. DOI: 10.1016/j.cell.2004.12.035. View

11.

Giraldez A, Cinalli R, Glasner M, Enright A, Thomson J, Baskerville S . MicroRNAs regulate brain morphogenesis in zebrafish. Science. 2005; 308(5723):833-8. DOI: 10.1126/science.1109020. View

12.

Beites C, Kawauchi S, Crocker C, Calof A . Identification and molecular regulation of neural stem cells in the olfactory epithelium. Exp Cell Res. 2005; 306(2):309-16. DOI: 10.1016/j.yexcr.2005.03.027. View

13.

Wienholds E, Kloosterman W, Miska E, Alvarez-Saavedra E, Berezikov E, de Bruijn E . MicroRNA expression in zebrafish embryonic development. Science. 2005; 309(5732):310-1. DOI: 10.1126/science.1114519. View

14.

Zhao Y, Samal E, Srivastava D . Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature. 2005; 436(7048):214-20. DOI: 10.1038/nature03817. View

15.

Harfe B, McManus M, Mansfield J, Hornstein E, Tabin C . The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A. 2005; 102(31):10898-903. PMC: 1182454. DOI: 10.1073/pnas.0504834102. View

16.

Kosik K, Krichevsky A . The Elegance of the MicroRNAs: A Neuronal Perspective. Neuron. 2005; 47(6):779-82. DOI: 10.1016/j.neuron.2005.08.019. View

17.

Kawauchi S, Shou J, Santos R, Hebert J, McConnell S, Mason I . Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development. 2005; 132(23):5211-23. DOI: 10.1242/dev.02143. View

18.

Li X, Carthew R . A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell. 2005; 123(7):1267-77. DOI: 10.1016/j.cell.2005.10.040. View

19.

Griffiths-Jones S, Grocock R, van Dongen S, Bateman A, Enright A . miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2005; 34(Database issue):D140-4. PMC: 1347474. DOI: 10.1093/nar/gkj112. View

20.

Schratt G, Tuebing F, Nigh E, Kane C, Sabatini M, Kiebler M . A brain-specific microRNA regulates dendritic spine development. Nature. 2006; 439(7074):283-9. DOI: 10.1038/nature04367. View