H Robert Horvitz
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Explore the profile of H Robert Horvitz including associated specialties, affiliations and a list of published articles.
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104
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9935
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Recent Articles
1.
Tucker N, Reddien P, Hersh B, Lee D, Liu M, Horvitz H
Sci Adv
. 2024 Oct;
10(41):eadn0325.
PMID: 39383227
In , apoptosis is inhibited by the BCL-2 homolog CED-9. Although canonically anti-apoptotic, CED-9 has a poorly understood pro-apoptotic function. CED-9 is thought to inhibit apoptosis by binding to and...
2.
Kong J, Ghosh D, Savvidis A, Sando S, Droste R, Horvitz H
bioRxiv
. 2024 Jul;
PMID: 39005398
How the HIF-1 (Hypoxia-Inducible) transcription factor drives and coordinates distinct responses to low oxygen across diverse cell types is poorly understood. We present a multi-tissue single-cell gene-expression atlas of the...
3.
Ahumada-Marchant C, Ancaten-Gonzalez C, Haensgen H, Brauer B, Merino-Veliz N, Droste R, et al.
BMC Biol
. 2024 Jun;
22(1):142.
PMID: 38926759
Background: The VPS50 protein functions in synaptic and dense core vesicle acidification, and perturbations of VPS50 function produce behavioral changes in Caenorhabditis elegans. Patients with mutations in VPS50 show severe...
4.
Doi A, Suarez G, Droste R, Horvitz H
Nat Commun
. 2023 Oct;
14(1):6593.
PMID: 37852948
How cells regulate gene expression in a precise spatiotemporal manner during organismal development is a fundamental question in biology. Although the role of transcriptional condensates in gene regulation has been...
5.
Kochersberger A, Torkashvand M, Lee D, Baskoylu S, Sengupta T, Koonce N, et al.
bioRxiv
. 2023 Sep;
PMID: 37745399
Programmed cell death is a common feature of animal development. During development of the hermaphrodite, programmed cell death (PCD) removes 131 cells from stereotyped positions in the cell lineage, mostly...
6.
Ahumada-Marchant C, Ancaten-Gonzalez C, Haensgen H, Arancibia F, Brauer B, Droste R, et al.
bioRxiv
. 2023 Jul;
PMID: 37461727
VPS50, is an accessory protein, involved in the synaptic and dense core vesicle acidification and its alterations produce behavioral changes in C.elegans. Here, we produce the mosaic knock out (mKO)...
7.
Saul J, Hirose T, Horvitz H
Elife
. 2022 Feb;
11.
PMID: 35119366
Cell identity is characterized by a distinct combination of gene expression, cell morphology, and cellular function established as progenitor cells divide and differentiate. Following establishment, cell identities can be unstable...
8.
Sando S, Bhatla N, Lee E, Horvitz H
Elife
. 2021 Jul;
10.
PMID: 34212858
Neural control of muscle function is fundamental to animal behavior. Many muscles can generate multiple distinct behaviors. Nonetheless, individual muscle cells are generally regarded as the smallest units of motor...
9.
Dwivedi V, Pardo-Pastor C, Droste R, Kong J, Tucker N, Denning D, et al.
Nature
. 2021 May;
593(7860):591-596.
PMID: 33953402
Cell extrusion is a mechanism of cell elimination that is used by organisms as diverse as sponges, nematodes, insects and mammals. During extrusion, a cell detaches from a layer of...
10.
Ghosh D, Lee D, Jin X, Horvitz H, Nitabach M
Science
. 2021 Mar;
371(6533):1059-1063.
PMID: 33674494
Color detection is used by animals of diverse phyla to navigate colorful natural environments and is thought to require evolutionarily conserved opsin photoreceptor genes. We report that roundworms can discriminate...