Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

Overview

Journal Science

Specialty Science

Date 1976 Sep 10

PMID 181845

Citations 586

Authors

D A Morgan

F W Ruscetti

R Gallo

Affiliations

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Abstract

Selective growth of T lymphocytes occurred when unfractionated normal human bone marrow cells were cultured with conditioned medium obtained from phytohemagglutinin-stimulated normal human lymphocytes (Ly-CM). Cultures of up to 90 percent T cells have been maintained for more than 9 months. The T cells exhibited a strict growth dependence upon Ly-CM and were consistently negative for Epstein-Barr viral information.

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