Targeting Systemic IL-2 to BCMA CAR-T Cells

Overview

Journal Nat Immunol

Date 2024 Oct 15

PMID 39406960

Authors

Yuzhe Shi

Michel Sadelain

Affiliations

Soon will be listed here.

References

Morgan D, Ruscetti F, Gallo R . Selective in vitro growth of T lymphocytes from normal human bone marrows. Science. 1976; 193(4257):1007-8. DOI: 10.1126/science.181845. View

Rakhshandehroo T, Mantri S, Moravej H, Louis B, Salehi Farid A, Munaretto L . A CAR enhancer increases the activity and persistence of CAR T cells. Nat Biotechnol. 2024; . PMC: 11779983. DOI: 10.1038/s41587-024-02339-4. View

June C, Sadelain M . Chimeric Antigen Receptor Therapy. N Engl J Med. 2018; 379(1):64-73. PMC: 7433347. DOI: 10.1056/NEJMra1706169. View

Quayle S, Girgis N, Thapa D, Merazga Z, Kemp M, Histed A . CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies. Clin Cancer Res. 2020; 26(8):1953-1964. DOI: 10.1158/1078-0432.CCR-19-3354. View

Lee C, Chen S, Berry C, Kelly A, Herman P, Oh S . Fate induction in CD8 CAR T cells through asymmetric cell division. Nature. 2024; 633(8030):670-677. PMC: 11410665. DOI: 10.1038/s41586-024-07862-7. View

Liu Y, Zhou N, Zhou L, Wang J, Zhou Y, Zhang T . IL-2 regulates tumor-reactive CD8 T cell exhaustion by activating the aryl hydrocarbon receptor. Nat Immunol. 2021; 22(3):358-369. DOI: 10.1038/s41590-020-00850-9. View

Cappell K, Kochenderfer J . A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains. Nat Rev Clin Oncol. 2021; 18(11):715-727. DOI: 10.1038/s41571-021-00530-z. View

Kagoya Y, Tanaka S, Guo T, Anczurowski M, Wang C, Saso K . A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects. Nat Med. 2018; 24(3):352-359. PMC: 5839992. DOI: 10.1038/nm.4478. View

Sockolosky J, Trotta E, Parisi G, Picton L, Su L, Le A . Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science. 2018; 359(6379):1037-1042. PMC: 5947856. DOI: 10.1126/science.aar3246. View

10.

Bell M, Lange S, Sejdiu B, Ibanez J, Shi H, Sun X . Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling. Nat Biomed Eng. 2023; 8(4):380-396. PMC: 11587785. DOI: 10.1038/s41551-023-01143-w. View

11.

Allen G, Frankel N, Reddy N, Bhargava H, Yoshida M, Stark S . Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science. 2022; 378(6625):eaba1624. PMC: 9970000. DOI: 10.1126/science.aba1624. View

12.

Li H, Israni D, Gagnon K, Gan K, Raymond M, Sander J . Multidimensional control of therapeutic human cell function with synthetic gene circuits. Science. 2022; 378(6625):1227-1234. PMC: 10054295. DOI: 10.1126/science.ade0156. View