Preparation and Evaluation of Chitosan/carrageenan Beads for Controlled Release of Sodium Diclofenac

Overview

Journal AAPS PharmSciTech

Publisher Springer

Specialty Pharmacology

Date 2008 Jan 10

PMID 18181557

Citations 24

Authors

Pimwipha Piyakulawat

Nalena Praphairaksit

Nuanphun Chantarasiri

Nongnuj Muangsin

Affiliations

Soon will be listed here.

Abstract

The polyelectrolyte complex (PEC) hydrogel beads based on chitosan (CS) and carrageenan (CR) have been studied as a controlled release device to deliver sodium diclofenac (DFNa) in the simulated gastrointestinal condition. Various factors potentially influencing the drug release (ie, CS/CR proportion, DFNa content, types and amount of cross-linking agents) were also investigated. The optimal formulation was obtained with CS/CR proportion of 2/1 and 5% (wt/vol) DFNa. The controlled release of the drug from this formulation was superior to other formulations and was able to maintain the release for approximately 8 hours. Upon cross-linking with glutaric acid and glutaraldehyde, the resulting beads were found to be more efficient for prolonged drug release than their non-cross-linking counterparts. The bead cross-linked with glutaraldehyde was able to control the release of the drug over 24 hours. The difference in the drug release behavior can be attributed to the differences in ionic interaction between the oppositely charged ions and to the concentrations of the drug within the beads, which depends on the compositions of the formulation and the pH of the dissolution medium. The release of drug was controlled by the mechanism of the dissolution of DFNa in the dissolution medium and the diffusion of DFNa through the hydrogel beads.

Citing Articles

Fixed-Dose Combination Formulations in Solid Oral Drug Therapy: Advantages, Limitations, and Design Features.

Wilkins C, Hamman H, Hamman J, Steenekamp J Pharmaceutics. 2024; 16(2).

PMID: 38399239 PMC: 10892518. DOI: 10.3390/pharmaceutics16020178.

Nanotechnology-driven improvisation of red algae-derived carrageenan for industrial and bio-medical applications.

James J, Verma M, Sharma N World J Microbiol Biotechnol. 2023; 40(1):4.

PMID: 37923917 DOI: 10.1007/s11274-023-03787-x.

pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery.

Vegad U, Patel M, Khunt D, Zupancic O, Chauhan S, Paudel A Front Bioeng Biotechnol. 2023; 11:1270364.

PMID: 37781530 PMC: 10540072. DOI: 10.3389/fbioe.2023.1270364.

pH-Responsive Hydrogel Beads Based on Alginate, κ-Carrageenan and Poloxamer for Enhanced Curcumin, Natural Bioactive Compound, Encapsulation and Controlled Release Efficiency.

Postolovic K, Antonijevic M, Ljujic B, Kovacevic M, Gazdic Jankovic M, Stanic Z Molecules. 2022; 27(13).

PMID: 35807288 PMC: 9268575. DOI: 10.3390/molecules27134045.

Toxicity Assessment and Control of Early Blight and Stem Rot of L. by Mancozeb-Loaded Chitosan-Gum Acacia Nanocomposites.

Kumar R, Duhan J, Manuja A, Kaur P, Kumar B, Sadh P J Xenobiot. 2022; 12(2):74-90.

PMID: 35466214 PMC: 9036208. DOI: 10.3390/jox12020008.

References

Gupta V, Hariharan M, Wheatley T, Price J . Controlled-release tablets from carrageenans: effect of formulation, storage and dissolution factors. Eur J Pharm Biopharm. 2001; 51(3):241-8. DOI: 10.1016/s0939-6411(01)00135-7. View

Gonzalez-Rodriguez M, Holgado M, Rabasco A, Fini A . Alginate/chitosan particulate systems for sodium diclofenac release. Int J Pharm. 2002; 232(1-2):225-34. DOI: 10.1016/s0378-5173(01)00915-2. View

Shu X, Zhu K . Controlled drug release properties of ionically cross-linked chitosan beads: the influence of anion structure. Int J Pharm. 2002; 233(1-2):217-25. DOI: 10.1016/s0378-5173(01)00943-7. View

de la Torre P, Enobakhare Y, Torrado G, Torrado S . Release of amoxicillin from polyionic complexes of chitosan and poly(acrylic acid). Study of polymer/polymer and polymer/drug interactions within the network structure. Biomaterials. 2003; 24(8):1499-506. DOI: 10.1016/s0142-9612(02)00512-4. View

Kim T, Park Y, Kim K, Cho C . Release of albumin from chitosan-coated pectin beads in vitro. Int J Pharm. 2003; 250(2):371-83. DOI: 10.1016/s0378-5173(02)00553-7. View

Tapia C, Escobar Z, Costa E, Sapag-Hagar J, Valenzuela F, Basualto C . Comparative studies on polyelectrolyte complexes and mixtures of chitosan-alginate and chitosan-carrageenan as prolonged diltiazem clorhydrate release systems. Eur J Pharm Biopharm. 2004; 57(1):65-75. DOI: 10.1016/s0939-6411(03)00153-x. View

Sanli O, Ay N, Isiklan N . Release characteristics of diclofenac sodium from poly(vinyl alcohol)/sodium alginate and poly(vinyl alcohol)-grafted-poly(acrylamide)/sodium alginate blend beads. Eur J Pharm Biopharm. 2006; 65(2):204-14. DOI: 10.1016/j.ejpb.2006.08.004. View

TOZAKI H, Komoike J, Tada C, Maruyama T, Terabe A, Suzuki T . Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon. J Pharm Sci. 1997; 86(9):1016-21. DOI: 10.1021/js970018g. View

Remunan-Lopez C, Alonso M . Development of new chitosan-cellulose multicore microparticles for controlled drug delivery. Eur J Pharm Biopharm. 1998; 45(1):49-56. DOI: 10.1016/S0939-6411(97)00122-7. View

10.

Puttipipatkhachorn S, Pongjanyakul T, Priprem A . Molecular interaction in alginate beads reinforced with sodium starch glycolate or magnesium aluminum silicate, and their physical characteristics. Int J Pharm. 2005; 293(1-2):51-62. DOI: 10.1016/j.ijpharm.2004.12.006. View

11.

Bodnar M, Hartmann J, Borbely J . Preparation and characterization of chitosan-based nanoparticles. Biomacromolecules. 2005; 6(5):2521-7. DOI: 10.1021/bm0502258. View

12.

Sankalia M, Mashru R, Sankalia J, Sutariya V . Papain entrapment in alginate beads for stability improvement and site-specific delivery: physicochemical characterization and factorial optimization using neural network modeling. AAPS PharmSciTech. 2005; 6(2):E209-22. PMC: 2750534. DOI: 10.1208/pt060231. View

13.

Sipahigil O, Gursoy A, Cakalagaoglu F, Okar I . Release behaviour and biocompatibility of drug-loaded pH sensitive particles. Int J Pharm. 2006; 311(1-2):130-8. DOI: 10.1016/j.ijpharm.2005.12.024. View

14.

Kurkuri M, Aminabhavi T . Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine. J Control Release. 2004; 96(1):9-20. DOI: 10.1016/j.jconrel.2003.12.025. View