Sulfated Seaweed Polysaccharides As Multifunctional Materials in Drug Delivery Applications

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2016 Mar 2

PMID 26927134

Citations 145

Authors

Ludmylla Cunha

Ana Grenha

Affiliations

Soon will be listed here.

Abstract

In the last decades, the discovery of metabolites from marine resources showing biological activity has increased significantly. Among marine resources, seaweed is a valuable source of structurally diverse bioactive compounds. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae and fucoidan in brown algae. Sulfated polysaccharides have been increasingly studied over the years in the pharmaceutical field, given their potential usefulness in applications such as the design of drug delivery systems. The purpose of this review is to discuss potential applications of these polymers in drug delivery systems, with a focus on carrageenan, ulvan and fucoidan. General information regarding structure, extraction process and physicochemical properties is presented, along with a brief reference to reported biological activities. For each material, specific applications under the scope of drug delivery are described, addressing in privileged manner particulate carriers, as well as hydrogels and beads. A final section approaches the application of sulfated polysaccharides in targeted drug delivery, focusing with particular interest the capacity for macrophage targeting.

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References

Kianfar F, Chowdhry B, Antonijevic M, Boateng J . Novel films for drug delivery via the buccal mucosa using model soluble and insoluble drugs. Drug Dev Ind Pharm. 2011; 38(10):1207-20. DOI: 10.3109/03639045.2011.644294. View

Wang W, Zhang P, Hao C, Zhang X, Cui Z, Guan H . In vitro inhibitory effect of carrageenan oligosaccharide on influenza A H1N1 virus. Antiviral Res. 2011; 92(2):237-46. DOI: 10.1016/j.antiviral.2011.08.010. View

Bhattacharyya S, Gill R, Chen M, Zhang F, Linhardt R, Dudeja P . Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells. J Biol Chem. 2008; 283(16):10550-8. PMC: 2447641. DOI: 10.1074/jbc.M708833200. View

Sezer A, Hatipoglu F, Cevher E, Ogurtan Z, Bas A, Akbuga J . Chitosan film containing fucoidan as a wound dressing for dermal burn healing: preparation and in vitro/in vivo evaluation. AAPS PharmSciTech. 2007; 8(2):Article 39. PMC: 2750378. DOI: 10.1208/pt0802039. View

Bulmer C, Margaritis A, Xenocostas A . Encapsulation and controlled release of recombinant human erythropoietin from chitosan-carrageenan nanoparticles. Curr Drug Deliv. 2012; 9(5):527-37. DOI: 10.2174/156720112802650680. View

Haug A . The influence of borate and calcium on the gel formation of a sulfated polysaccharide from Ulva lactuca. Acta Chem Scand B. 1976; 30(6):562-6. DOI: 10.3891/acta.chem.scand.30b-0562. View

Pangestuti R, Kim S . Biological activities of carrageenan. Adv Food Nutr Res. 2014; 72:113-124. DOI: 10.1016/B978-0-12-800269-8.00007-5. View

Cumashi A, Ushakova N, Preobrazhenskaya M, DIncecco A, Piccoli A, Totani L . A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology. 2007; 17(5):541-52. DOI: 10.1093/glycob/cwm014. View

Liu Y, Yao W, Wang S, Di G, Zheng Q, Chen A . Preparation and characterization of fucoidan-chitosan nanospheres by the sonification method. J Nanosci Nanotechnol. 2014; 14(5):3844-9. DOI: 10.1166/jnn.2014.8026. View

10.

Kusaikin M, Chizhov A, Alekseeva S, Bakunina I, Nedashkovskaya O, Sova V . A comparative study of the specificity of fucoidanases of marine microorganisms and invertebrates. Dokl Biochem Biophys. 2004; 396:187-9. DOI: 10.1023/b:dobi.0000033525.32259.15. View

11.

Kianfar F, Antonijevic M, Chowdhry B, Boateng J . Lyophilized wafers comprising carrageenan and pluronic acid for buccal drug delivery using model soluble and insoluble drugs. Colloids Surf B Biointerfaces. 2012; 103:99-106. DOI: 10.1016/j.colsurfb.2012.10.006. View

12.

Mohamadnia Z, Zohuriaan-Mehr M, Kabiri K, Jamshidi A, Mobedi H . Ionically cross-linked carrageenan-alginate hydrogel beads. J Biomater Sci Polym Ed. 2008; 19(1):47-59. DOI: 10.1163/156856208783227640. View

13.

Jiang Z, Okimura T, Yamaguchi K, Oda T . The potent activity of sulfated polysaccharide, ascophyllan, isolated from Ascophyllum nodosum to induce nitric oxide and cytokine production from mouse macrophage RAW264.7 cells: Comparison between ascophyllan and fucoidan. Nitric Oxide. 2011; 25(4):407-15. DOI: 10.1016/j.niox.2011.10.001. View

14.

Yuan H, Song J, Li X, Li N, Dai J . Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides. Cancer Lett. 2006; 243(2):228-34. DOI: 10.1016/j.canlet.2005.11.032. View

15.

Alves A, Pinho E, Neves N, Sousa R, Reis R . Processing ulvan into 2D structures: cross-linked ulvan membranes as new biomaterials for drug delivery applications. Int J Pharm. 2012; 426(1-2):76-81. DOI: 10.1016/j.ijpharm.2012.01.021. View

16.

Kwak J . Fucoidan as a marine anticancer agent in preclinical development. Mar Drugs. 2014; 12(2):851-70. PMC: 3944519. DOI: 10.3390/md12020851. View

17.

Zhu L, Chen L, Cao Q, Chen D, Cui J . Preparation and evaluation of mannose receptor mediated macrophage targeting delivery system. J Control Release. 2011; 152 Suppl 1:e190-1. DOI: 10.1016/j.jconrel.2011.08.082. View

18.

Maretti E, Rossi T, Bondi M, Croce M, Hanuskova M, Leo E . Inhaled Solid Lipid Microparticles to target alveolar macrophages for tuberculosis. Int J Pharm. 2013; 462(1-2):74-82. DOI: 10.1016/j.ijpharm.2013.12.034. View

19.

Daniel-da-Silva A, Ferreira L, Gil A, Trindade T . Synthesis and swelling behavior of temperature responsive κ-carrageenan nanogels. J Colloid Interface Sci. 2011; 355(2):512-7. DOI: 10.1016/j.jcis.2010.12.071. View

20.

Jaulneau V, Lafitte C, Jacquet C, Fournier S, Salamagne S, Briand X . Ulvan, a sulfated polysaccharide from green algae, activates plant immunity through the jasmonic acid signaling pathway. J Biomed Biotechnol. 2010; 2010:525291. PMC: 2860583. DOI: 10.1155/2010/525291. View