Preparation, Characterization, and Potential Application of Chitosan, Chitosan Derivatives, and Chitosan Metal Nanoparticles in Pharmaceutical Drug Delivery

Overview

Journal Drug Des Devel Ther

Specialty Pharmacology

Date 2016 Feb 13

PMID 26869768

Citations 150

Authors

Tarek A Ahmed

Bader M Aljaeid

Affiliations

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Abstract

Naturally occurring polymers, particularly of the polysaccharide type, have been used pharmaceutically for the delivery of a wide variety of therapeutic agents. Chitosan, the second abundant naturally occurring polysaccharide next to cellulose, is a biocompatible and biodegradable mucoadhesive polymer that has been extensively used in the preparation of micro-as well as nanoparticles. The prepared particles have been exploited as a potential carrier for different therapeutic agents such as peptides, proteins, vaccines, DNA, and drugs for parenteral and nonparenteral administration. Therapeutic agent-loaded chitosan micro- or nanoparticles were found to be more stable, permeable, and bioactive. In this review, we are highlighting the different methods of preparation and characterization of chitosan micro- and nanoparticles, while reviewing the pharmaceutical applications of these particles in drug delivery. Moreover, the roles of chitosan derivatives and chitosan metal nanoparticles in drug delivery have been illustrated.

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References

Agnihotri S, Aminabhavi T . Controlled release of clozapine through chitosan microparticles prepared by a novel method. J Control Release. 2004; 96(2):245-59. DOI: 10.1016/j.jconrel.2004.01.025. View

Jameela S, Kumary T, Lal A, Jayakrishnan A . Progesterone-loaded chitosan microspheres: a long acting biodegradable controlled delivery system. J Control Release. 1998; 52(1-2):17-24. DOI: 10.1016/s0168-3659(97)00187-9. View

Kang M, Jiang H, Kang S, Guo D, Lee D, Cho C . Pluronic F127 enhances the effect as an adjuvant of chitosan microspheres in the intranasal delivery of Bordetella bronchiseptica antigens containing dermonecrotoxin. Vaccine. 2007; 25(23):4602-10. DOI: 10.1016/j.vaccine.2007.03.038. View

Corrigan D, Healy A, Corrigan O . Preparation and release of salbutamol from chitosan and chitosan co-spray dried compacts and multiparticulates. Eur J Pharm Biopharm. 2005; 62(3):295-305. DOI: 10.1016/j.ejpb.2005.09.008. View

Ubaidulla U, Sultana Y, Ahmed F, Khar R, Panda A . Chitosan phthalate microspheres for oral delivery of insulin: preparation, characterization, and in vitro evaluation. Drug Deliv. 2006; 14(1):19-23. DOI: 10.1080/10717540600559478. View

Basu S, Kavitha K, Rupeshkumar M . Evaluation of ketorolac tromethamine microspheres by chitosan/gelatin B complex coacervation. Sci Pharm. 2010; 78(1):79-92. PMC: 3002822. DOI: 10.3797/scipharm.0903-16. View

Dautry-Varsat A . Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor. Biochimie. 1986; 68(3):375-81. DOI: 10.1016/s0300-9084(86)80004-9. View

Wadhwa S, Paliwal R, Paliwal S, Vyas S . Hyaluronic acid modified chitosan nanoparticles for effective management of glaucoma: development, characterization, and evaluation. J Drug Target. 2009; 18(4):292-302. DOI: 10.3109/10611860903450023. View

Agnihotri S, Mallikarjuna N, Aminabhavi T . Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J Control Release. 2004; 100(1):5-28. DOI: 10.1016/j.jconrel.2004.08.010. View

10.

Palecanda A, Kobzik L . Receptors for unopsonized particles: the role of alveolar macrophage scavenger receptors. Curr Mol Med. 2002; 1(5):589-95. DOI: 10.2174/1566524013363384. View

11.

Wang J, Tan H, Yu A, Ling P, Lou H, Zhai G . Preparation of chitosan-based nanoparticles for delivery of low molecular weight heparin. J Biomed Nanotechnol. 2011; 7(5):696-703. DOI: 10.1166/jbn.2011.1326. View

12.

Prabaharan M . Chitosan-based nanoparticles for tumor-targeted drug delivery. Int J Biol Macromol. 2014; 72:1313-22. DOI: 10.1016/j.ijbiomac.2014.10.052. View

13.

Gan Q, Wang T . Chitosan nanoparticle as protein delivery carrier--systematic examination of fabrication conditions for efficient loading and release. Colloids Surf B Biointerfaces. 2007; 59(1):24-34. DOI: 10.1016/j.colsurfb.2007.04.009. View

14.

Kockisch S, Rees G, Young S, Tsibouklis J, Smart J . Polymeric microspheres for drug delivery to the oral cavity: an in vitro evaluation of mucoadhesive potential. J Pharm Sci. 2003; 92(8):1614-23. DOI: 10.1002/jps.10423. View

15.

Varshosaz J, Jaffarian Dehkordi A, Golafshan S . Colon-specific delivery of mesalazine chitosan microspheres. J Microencapsul. 2006; 23(3):329-39. DOI: 10.1080/02652040600612405. View

16.

Li X, Kong X, Shi S, Zheng X, Guo G, Wei Y . Preparation of alginate coated chitosan microparticles for vaccine delivery. BMC Biotechnol. 2008; 8:89. PMC: 2603011. DOI: 10.1186/1472-6750-8-89. View

17.

Casettari L, Castagnino E, Stolnik S, Lewis A, Howdle S, Illum L . Surface characterisation of bioadhesive PLGA/chitosan microparticles produced by supercritical fluid technology. Pharm Res. 2011; 28(7):1668-82. DOI: 10.1007/s11095-011-0403-z. View

18.

Zhang Y, Chan H, Leong K . Advanced materials and processing for drug delivery: the past and the future. Adv Drug Deliv Rev. 2012; 65(1):104-20. PMC: 3565095. DOI: 10.1016/j.addr.2012.10.003. View

19.

Sahoo S, Parveen S, Panda J . The present and future of nanotechnology in human health care. Nanomedicine. 2007; 3(1):20-31. DOI: 10.1016/j.nano.2006.11.008. View

20.

Rodrigues S, Cordeiro C, Seijo B, Remunan-Lopez C, Grenha A . Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: Stability and toxicological evaluation. Carbohydr Polym. 2015; 123:369-80. DOI: 10.1016/j.carbpol.2015.01.048. View