SOCS1 is an Inducible Host Factor During HIV-1 Infection and Regulates the Intracellular Trafficking and Stability of HIV-1 Gag

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2008 Jan 4

PMID 18172216

Citations 50

Authors

Akihide Ryo

Naomi Tsurutani

Kenji Ohba

Ryuichiro Kimura

Jun Komano

Mayuko Nishi

Hiromi Soeda

Shinichiro Hattori

Kilian Perrem

Mikio Yamamoto

Joe Chiba

Jun-Ichi Mimaya

Kazuhisa Yoshimura

Shuzo Matsushita

Mitsuo Honda

Akihiko Yoshimura

Tatsuya Sawasaki

Ichiro Aoki

Yuko Morikawa

Naoki Yamamoto

Affiliations

Soon will be listed here.

Abstract

Human immunodeficiency virus type 1 (HIV-1) utilizes the macromolecular machinery of the infected host cell to produce progeny virus. The discovery of cellular factors that participate in HIV-1 replication pathways has provided further insight into the molecular basis of virus-host cell interactions. Here, we report that the suppressor of cytokine signaling 1 (SOCS1) is an inducible host factor during HIV-1 infection and regulates the late stages of the HIV-1 replication pathway. SOCS1 can directly bind to the matrix and nucleocapsid regions of the HIV-1 p55 Gag polyprotein and enhance its stability and trafficking, resulting in the efficient production of HIV-1 particles via an IFN signaling-independent mechanism. The depletion of SOCS1 by siRNA reduces both the targeted trafficking and assembly of HIV-1 Gag, resulting in its accumulation as perinuclear solid aggregates that are eventually subjected to lysosomal degradation. These results together indicate that SOCS1 is a crucial host factor that regulates the intracellular dynamism of HIV-1 Gag and could therefore be a potential new therapeutic target for AIDS and its related disorders.

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