Psoriasis is Associated with Increased Beta-defensin Genomic Copy Number

Overview

Journal Nat Genet

Specialty Genetics

Date 2007 Dec 7

PMID 18059266

Citations 293

Authors

Edward J Hollox

Ulrike Huffmeier

Patrick L J M Zeeuwen

Raquel Palla

Jesus Lascorz

Diana Rodijk-Olthuis

Peter C M van de Kerkhof

Heiko Traupe

Gys de Jongh

Martin den Heijer

Andre Reis

John A L Armour

Joost Schalkwijk

Affiliations

Soon will be listed here.

Abstract

Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.

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