Copper(II) Carboxylate-promoted Intramolecular Carboamination of Alkenes for the Synthesis of Polycyclic Lactams

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2007 Nov 30

PMID 18044907

Citations 15

Authors

Peter H Fuller

Sherry R Chemler

Affiliations

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Abstract

The copper(II) carboxylate-promoted intramolecular carboamination reactions of variously substituted gamma-alkenyl amides have been investigated. These oxidative cyclization reactions efficiently provide polycyclic lactams, useful intermediates in nitrogen heterocycle synthesis, in good to excellent yields. The efficiency of the carboamination process is dependent upon the structure of the amide backbone as well as the nitrogen substituent.

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