Sherry R Chemler
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Explore the profile of Sherry R Chemler including associated specialties, affiliations and a list of published articles.
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66
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1162
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Recent Articles
1.
Lama R, Fose J, Martin D, Munoz I, Wang E, Sung P, et al.
Molecules
. 2025 Jan;
30(1).
PMID: 39795242
MDM2 and MDM4 are major negative regulators of tumor suppressor p53. Beyond regulating p53, MDM2 possesses p53-independent activity in promoting cell cycle progression and tumorigenesis via its RING domain ubiquitin...
2.
Lama R, Wu W, Mavis C, Ruiz F, Querol-Garcia J, Martin D, et al.
Front Oncol
. 2025 Jan;
14:1462231.
PMID: 39763603
Rituximab combined with systemic chemotherapy significantly improves the rate of complete response in B-cell lymphomas. However, acquired rituximab resistance develops in most patients leading to relapse. The mechanisms underlying rituximab...
3.
Chemler S
ARKIVOC
. 2024 Nov;
2024(2).
PMID: 39507303
Nitrogen-centered radicals are reactive intermediates that can function in the formation of new C-N bonds or enable the formation of other bonds through their ability to abstract hydrogen atoms to...
4.
Kennedy-Ellis J, Kelleher A, Sayeed J, Burde A, Chemler S
J Org Chem
. 2024 Jan;
89(2):1256-1263.
PMID: 38194284
The rapid synthesis of a range of enantioenriched allylic esters is enabled by a new 3-component catalytic enantioselective 1,2-carboesterification of readily available dienes with carboxylic acids and potassium alkyltrifluoroborates. The...
5.
Carmo R, Galster S, Wdowik T, Song C, Chemler S
J Am Chem Soc
. 2023 Jun;
145(25):13715-13729.
PMID: 37327484
Alkene aminooxygenation and dioxygenation reactions that result in carbonyl products are uncommon, and protocols that control absolute stereochemistry are rare. We report herein catalytic enantioselective alkene aminooxygenation and dioxygenation that...
6.
Burde A, Chemler S
ACS Catal
. 2023 Mar;
12(13):7559-7564.
PMID: 36937986
Saturated heterocycles containing oxygen and sulfur are found in biologically significant molecules. The enantioselective oxysulfenylation of alkenols provides a straightforward synthesis route. To date, organocatalytic methods have dominated this approach....
7.
Lama R, Galster S, Xu C, Davison L, Chemler S, Wang X
Molecules
. 2022 Nov;
27(22).
PMID: 36431769
MDM2 and MDM4 are cancer drug targets validated in multiple models for p53-based cancer therapies. The RING domains of MDM2 and non-p53-binder MDM2 splice isoforms form RING domain heterodimer polyubiquitin...
8.
Lama R, Xu C, Galster S, Querol-Garcia J, Portwood S, Mavis C, et al.
Front Oncol
. 2022 Aug;
12:933446.
PMID: 35992795
MDM2 and MDM4 proteins are key negative regulators of tumor suppressor p53. MDM2 and MDM4 interact their RING domains and form a heterodimer polyubiquitin E3 ligase essential for p53 degradation....
9.
Vignieri S, Smith K, Hurtley S, Zahn L, Gao W, Fogg C, et al.
Science
. 2022 Mar;
376(6588):59-61.
PMID: 35357916
Highlights from the family of journals.
10.
Li J, Lama R, Galster S, Inigo J, Wu J, Chandra D, et al.
Mol Cancer Ther
. 2022 Feb;
21(4):535-545.
PMID: 35131878
High frequency of KRAS and TP53 mutations is a unique genetic feature of pancreatic ductal adenocarcinoma (PDAC). TP53 mutation not only renders PDAC resistance to chemotherapies but also drives PDAC...