Synthesis and Biological Activities of Some New Fluorinated Coumarins and 1-aza Coumarins

Overview

Journal Eur J Med Chem

Specialty Chemistry

Date 2007 Oct 26

PMID 17959273

Citations 15

Authors

Rajesh G Kalkhambkar

Geeta M Kulkarni

Chandrappa M Kamanavalli

N Premkumar

S M B Asdaq

Chung Ming Sun

Affiliations

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Abstract

A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, 19F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein.

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