Antibiofilm Activity of Plant Polyphenols

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2016 Dec 17

PMID 27983597

Citations 90

Authors

Livia Slobodnikova

Silvia Fialova

Katarina Rendekova

Jan Kovac

Pavel Mucaji

Affiliations

Soon will be listed here.

Abstract

In the history of human medicine, antibiotics represent epochal examples of medical progress. However, with an approaching antibiotic crisis due to the emergence and extensive spread of antimicrobial resistance among bacterial agents, as well as to increasing number of patients with chronic and recalcitrant bacterial biofilm-associated infections, the naturally occurring molecules may become new sources of antibacterial and antibiofilm drugs for clinical usage. Polyphenols represent a class of plant natural products which are important in plant defense against microbial pathogens. The main focus of the review is on the antibiofilm activities of phenolic compounds against bacteria which play an essential role in medical device biofilm-associated infections. The other, not negligible part of the review is devoted to polyphenols' activity against bacterial agents that cause dental caries and periodontal disease.

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