Design and Synthesis of Manganese Porphyrins with Tailored Lipophilicity: Investigation of Redox Properties and Superoxide Dismutase Activity

Overview

Journal Bioorg Med Chem

Specialties Biochemistry
Chemistry

Date 2007 Sep 8

PMID 17822908

Citations 18

Authors

Dorothee Lahaye

Kannan Muthukumaran

Chen-Hsiung Hung

Dorota Gryko

Julio S Reboucas

Ivan Spasojevic

Ines Batinic-Haberle

Jonathan S Lindsey

Affiliations

Soon will be listed here.

Abstract

Thirteen new manganese porphyrins and two porphodimethenes bearing one to three different substituents at the meso positions in a variety of architectures have been synthesized. The substituents employed generally are (i) electron-withdrawing to tune the reduction potential to the desirable range (near +0.3V vs NHE), and/or (ii) lipophilic to target the interior of lipid bilayer membranes and/or the blood-brain barrier. The influence of the substituents on the Mn(III)/Mn(II) reduction potentials has been characterized, and the superoxide dismutase activity of the compounds has been examined.

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