How Do Transplanted Olfactory Ensheathing Cells Restore Function?

Overview

Journal Brain Res Brain Res Rev

Specialty Neurology

Date 2003 Feb 19

PMID 12589931

Citations 10

Authors

N Keyvan-Fouladi

Y Li

G Raisman

Affiliations

Soon will be listed here.

Abstract

In this article, we review our work on regeneration of the corticospinal tract in rats following a lesion at upper cervical level. We outline the rationale for using olfactory ensheathing cells, and summarize the evidence for regeneration and functional recovery. The present interpretation on the mechanisms of functional recovery is partly hypothetical, and we emphasize where further experimental evidence is needed.

Citing Articles

Current and future medical therapeutic strategies for the functional repair of spinal cord injury.

Yilmaz T, Kaptanoglu E World J Orthop. 2015; 6(1):42-55.

PMID: 25621210 PMC: 4303789. DOI: 10.5312/wjo.v6.i1.42.

Cellular therapies for treating pain associated with spinal cord injury.

Leung L J Transl Med. 2012; 10:37.

PMID: 22394650 PMC: 3320547. DOI: 10.1186/1479-5876-10-37.

Cell therapy for multiple sclerosis.

Ben-Hur T Neurotherapeutics. 2011; 8(4):625-42.

PMID: 21904787 PMC: 3250283. DOI: 10.1007/s13311-011-0073-x.

Slow- and fast-twitch rat hind limb skeletal muscle phenotypes 8 months after spinal cord transection and olfactory ensheathing glia transplantation.

Negredo P, Rivero J, Gonzalez B, Ramon-Cueto A, Manso R J Physiol. 2008; 586(10):2593-610.

PMID: 18372308 PMC: 2464339. DOI: 10.1113/jphysiol.2007.149120.

Remyelination of the injured spinal cord.

Sasaki M, Li B, Lankford K, Radtke C, Kocsis J Prog Brain Res. 2007; 161:419-33.

PMID: 17618995 PMC: 2605400. DOI: 10.1016/S0079-6123(06)61030-3.