C-C Bond Formation Via Double C-H Functionalization: Aerobic Oxidative Coupling As a Method for Synthesizing Heterocoupled Biaryls

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2007 Jul 10

PMID 17616203

Citations 37

Authors

Timothy A Dwight

Nicholas R Rue

Dagmara Charyk

Ryan Josselyn

Brenton DeBoef

Affiliations

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Abstract

The aerobic oxidative coupling of arenes such as benzofuran and N-substituted indoles with benzene and derivatives thereof is described. The reaction is shown to take place in both inter- and intramolecular scenarios.

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Catalyst-Controlled Regioselectivity in Pd-Catalyzed Aerobic Oxidative Arylation of Indoles.

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