Highly Regioselective Catalytic Oxidative Coupling Reactions: Synthetic and Mechanistic Investigations

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2006 Oct 26

PMID 17061885

Citations 40

Authors

Kami L Hull

Erica L Lanni

Melanie S Sanford

Affiliations

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Abstract

A highly efficient and regioselective Pd-catalyzed method for the oxidative coupling of arylpyridine derivatives is reported. Remarkably, the reactions proceed at room temperature and are compatible with diverse functionalities, including aryl halides and thiophenes. Mechanistic studies suggest that these transformations proceed via a previously unprecedented mechanism involving two different pyridine-directed C-H activation reactions-one at a PdII center and one at PdIV.

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