Fusarium Toxins of the Scirpentriol Subgroup: a Review

Overview

Journal Mycopathologia

Specialties Microbiology
Pharmacology

Date 2007 Jul 5

PMID 17610049

Citations 14

Authors

Margit Schollenberger

Winfried Drochner

Hans-Martin Muller

Affiliations

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Abstract

Scirpentriol and its seven acetylated derivatives comprise a family of type-A trichothecene toxins produced by several species of Fusarium fungi. Out of this group 4,15-diacetoxyscirpenol has attracted most attention. It elicits toxic responses in several species and was detected in a variety of substrates. Out of the three possible monoacetylated derivatives 15-monoacetoxyscirpenol and the parent alcohol scirpentriol received some attention, whereas the remaining members of the family were mentioned in few reports. The present review deals with the structure, biosynthesis, analysis and toxicity of scirpentriol toxins. Formation by Fusarium species as well as culture conditions used for toxigenicity studies are reviewed; data about the natural occurrence of scirpentriol toxins in different cereal types, cereal associated products as well as in non-grain matrices including potato and soya bean are reported. Basing on literature reports about the toxicity of scirpentriol toxins an attempt is made to summarise the state of knowledge for risk evaluation for human and animal health.

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References

Berger U, Oehme M, Kuhn F . Quantitative determination and structure elucidation of type A- and B-trichothecenes by HPLC/ion trap multiple mass spectrometry. J Agric Food Chem. 1999; 47(10):4240-5. DOI: 10.1021/jf9904012. View

Desjardins A, Hohn T, McCormick S . Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance. Microbiol Rev. 1993; 57(3):595-604. PMC: 372927. DOI: 10.1128/mr.57.3.595-604.1993. View

Schollenberger M, Lauber U, Jara H, SUCHY S, Drochner W, Muller H . Determination of eight trichothecenes by gas chromatography-mass spectrometry after sample clean-up by a two-stage solid-phase extraction. J Chromatogr A. 1998; 815(1):123-32. DOI: 10.1016/s0021-9673(98)00454-3. View

Hasan H . Phytotoxicity of pathogenic fungi and their mycotoxins to cereal seedling viability. Mycopathologia. 2001; 148(3):149-55. DOI: 10.1023/a:1007164617175. View

Sugiura Y, Fukasaku K, Tanaka T, Matsui Y, Ueno Y . Fusarium poae and Fusarium crookwellense, Fungi Responsible for the Natural Occurrence of Nivalenol in Hokkaido. Appl Environ Microbiol. 1993; 59(10):3334-8. PMC: 182456. DOI: 10.1128/aem.59.10.3334-3338.1993. View

Muller H . Gluconate accumulation and enzyme activities with extremely nitrogen-limited surface cultures of Aspergillus niger. Arch Microbiol. 1986; 144(2):151-7. DOI: 10.1007/BF00414726. View

Thrane U, Hansen U . Chemical and physiological characterization of taxa in the Fusarium sambucinum complex. Mycopathologia. 1995; 129(3):183-90. DOI: 10.1007/BF01103345. View

Cavaliere C, Foglia P, Pastorini E, Samperi R, Lagana A . Development of a multiresidue method for analysis of major Fusarium mycotoxins in corn meal using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005; 19(14):2085-93. DOI: 10.1002/rcm.2030. View

Mateo J, Mateo R, Hinojo M, Llorens A, Jimenez M . Liquid chromatographic determination of toxigenic secondary metabolites produced by Fusarium strains. J Chromatogr A. 2002; 955(2):245-56. DOI: 10.1016/s0021-9673(02)00214-5. View

10.

Nordby K, Halstensen A, Elen O, Clasen P, Langseth W, Kristensen P . Trichothecene mycotoxins and their determinants in settled dust related to grain production. Ann Agric Environ Med. 2004; 11(1):75-83. View

11.

Hohn T, McCormick S, Desjardins A . Evidence for a gene cluster involving trichothecene-pathway biosynthetic genes in Fusarium sporotrichioides. Curr Genet. 1993; 24(4):291-5. DOI: 10.1007/BF00336778. View

12.

Muller H, Reimann J, Schumacher U, Schwadorf K . Natural occurrence of Fusarium toxins in barley harvested during five years in an area of southwest Germany. Mycopathologia. 1997; 137(3):185-92. DOI: 10.1023/A:1006805717043. View

13.

Morrison E, Rundberget T, Kosiak B, Aastveit A, Bernhoft A . Cytotoxicity of trichothecenes and fusarochromanone produced by Fusarium equiseti strains isolated from Norwegian cereals. Mycopathologia. 2002; 153(1):49-56. DOI: 10.1023/a:1015201709070. View

14.

Perkowski J, Kiecana I, Stachowiak J, Basinski T . Natural occurrence of scirpentriol in cereals infected by Fusarium species. Food Addit Contam. 2003; 20(6):572-8. DOI: 10.1080/0265203031000100773. View

15.

Nielsen K, Thrane U . Fast methods for screening of trichothecenes in fungal cultures using gas chromatography-tandem mass spectrometry. J Chromatogr A. 2001; 929(1-2):75-87. DOI: 10.1016/s0021-9673(01)01174-8. View

16.

Klotzel M, Gutsche B, Lauber U, Humpf H . Determination of 12 type A and B trichothecenes in cereals by liquid chromatography-electrospray ionization tandem mass spectrometry. J Agric Food Chem. 2005; 53(23):8904-10. DOI: 10.1021/jf051501c. View

17.

Mirocha C, Pathre S, Schauerhamer B, Christensen C . Natural occurrence of Fusarium toxins in feedstuff. Appl Environ Microbiol. 1976; 32(4):553-6. PMC: 170304. DOI: 10.1128/aem.32.4.553-556.1976. View

18.

Langseth W, Bernhoft A, Rundberget T, Kosiak B, Gareis M . Mycotoxin production and cytotoxicity of Fusarium strains isolated from Norwegian cereals. Mycopathologia. 1999; 144(2):103-13. DOI: 10.1023/a:1007016820879. View

19.

Furlong E, Soares L, Lasca C, Kohara E . Mycotoxins and fungi in wheat harvested during 1990 in test plots in the state of São Paulo, Brazil. Mycopathologia. 1995; 131(3):185-90. DOI: 10.1007/BF01102899. View

20.

Sforza S, DallAsta C, Marchelli R . Recent advances in mycotoxin determination in food and feed by hyphenated chromatographic techniques/mass spectrometry. Mass Spectrom Rev. 2005; 25(1):54-76. DOI: 10.1002/mas.20052. View