Control of C. Elegans Hermaphrodite Gonad Size and Shape by Vab-3/Pax6-mediated Regulation of Integrin Receptors

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2007 Jul 4

PMID 17606640

Citations 42

Authors

Christopher M Meighan

Jean E Schwarzbauer

Affiliations

Soon will be listed here.

Abstract

Integrin receptors for extracellular matrix are critical for cell motility, but the signals that determine when to stop are not known. Analysis of distal tip cell (DTC) migration during gonadogenesis in Caenorhabditis elegans has revealed the importance of transcription factor vab-3/Pax6 in regulating the alpha integrin genes, ina-1 and pat-2. Utilizing vab-3 mutants, we show that the down-regulation of ina-1 is necessary for DTC migration cessation and the up-regulation of pat-2 is required for directionality. These results demonstrate concomitant, but distinct roles in migration for each integrin. Notably, transcriptional control of migration termination provides a new mechanism for regulation of morphogenesis and organ size.

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