Dietary Omega-3-polyunsaturated Fatty Acids Prevent the Development of Metastases of Colon Carcinoma in Rat Liver

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2007 Jun 27

PMID 17593466

Citations 11

Authors

Carsten N Gutt

Lars Brinkmann

Arianeb Mehrabi

Hamidreza Fonouni

Beat P Muller-Stich

Gregor Vetter

Jurgen M Stein

Peter Schemmer

Markus W Buchler

Affiliations

Soon will be listed here.

Abstract

Background: Fish oil consisting of omega-3 polyunsaturated fatty acids (PUFA) seems to reduce the incidence of colon cancer. The effect of PUFAs on metastasis of colon carcinoma is still unclear.

Aim: The study was designed to examine the effects of a diet rich in omega-3-PUFAs on a model of colorectal metastasis.

Methods: Thirty animals (WAG/Rij) were randomly assigned to receive an omega-3 diet or a control diet to evaluate their effect on tumor growth. The target male rats (WAG/Rij) were fed a diet containing 15% omega-3-fatty acids three days before and 28 days after intervention and the control rats received 15% coconut oil at the same time points. CC 531 cells, a moderately differentiated colon adenocarcinoma, were injected into the spleen of each rat. After 28 days of diet, animals were sacrificed. The tumor growth was evaluated macroscopically and microscopically in liver tissue. The tissue was examined after immunostaining and the use of monoclonal antibodies.

Results: PUFAs decreased the index of tumor load from 1.54 in the controls to 0.79 in the treatment group (P = 0.036). While 69.2% of the control animals were tumor positive, only 21.4% of the target animals showed tumor after omega-3-fatty acid (P < 0.05).

Conclusion: We could show that omega-3-fatty acids may decrease malignant metastatic tumor growth in the liver.

Citing Articles

Fish Consumption and Colorectal Cancer Risk: Meta-Analysis of Prospective Epidemiological Studies and Review of Evidence from Animal Studies.

Caini S, Chioccioli S, Pastore E, Fontana M, Tortora K, Caderni G Cancers (Basel). 2022; 14(3).

PMID: 35158907 PMC: 8833371. DOI: 10.3390/cancers14030640.

ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved.

Tu M, Wang W, Zhang G, Hammock B Nutrients. 2020; 12(11).

PMID: 33126566 PMC: 7693568. DOI: 10.3390/nu12113301.

Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer.

Michalak A, Mosinska P, Fichna J Front Pharmacol. 2016; 7:459.

PMID: 27990120 PMC: 5131004. DOI: 10.3389/fphar.2016.00459.

Prevention of diabetes-promoted colorectal cancer by (n-3) polyunsaturated fatty acids and (n-3) PUFA mimetic.

Algamas-Dimantov A, Yehuda-Shnaidman E, Hertz R, Peri I, Bar-Tana J, Schwartz B Oncotarget. 2014; 5(20):9851-63.

PMID: 25375205 PMC: 4259442. DOI: 10.18632/oncotarget.2453.

Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer.

Merendino N, Costantini L, Manzi L, Molinari R, DEliseo D, Velotti F Biomed Res Int. 2013; 2013:310186.

PMID: 23762838 PMC: 3676987. DOI: 10.1155/2013/310186.

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