Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer

Overview

Journal Front Pharmacol

Date 2016 Dec 20

PMID 27990120

Citations 41

Authors

Arkadiusz Michalak

Paula Mosinska

Jakub Fichna

Affiliations

Soon will be listed here.

Abstract

Polyunsaturated fatty acids (PUFAs) are bioactive lipids which modulate inflammation and immunity. They gained recognition in nutritional therapy and are recommended dietary supplements. There is a growing body of evidence suggesting the usefulness of PUFAs in active therapy of various gastrointestinal (GI) diseases. In this review we briefly cover the systematics of PUFAs and their metabolites, and elaborate on their possible use in inflammatory bowel disease (IBD), functional gastrointestinal disorders (FGIDs) with focus on irritable bowel syndrome (IBS), and colorectal cancer (CRC). Each section describes the latest findings from and studies, with reports of clinical interventions when available.

Citing Articles

Chloride channels and mast cell function: pioneering new frontiers in IBD therapy.

Aljameeli A, Alsuwayt B, Bharati D, Gohri V, Mohite P, Singh S Mol Cell Biochem. 2025; .

PMID: 40038149 DOI: 10.1007/s11010-025-05243-w.

Immune cells mediate the effects of gut microbiota on neuropathic pain: a Mendelian randomization study.

Pan H, Liu C, Zhu H, Zhang G J Headache Pain. 2024; 25(1):196.

PMID: 39528917 PMC: 11555962. DOI: 10.1186/s10194-024-01906-z.

What defines a healthy gut microbiome?.

Van Hul M, Cani P, Petitfils C, de Vos W, Tilg H, El-Omar E Gut. 2024; 73(11):1893-1908.

PMID: 39322314 PMC: 11503168. DOI: 10.1136/gutjnl-2024-333378.

The gut microbiota-neuroimmune crosstalk and neuropathic pain: a scoping review.

Nawarathna G, Fakhruddin K, Shorbagi A, Samaranayake L Gut Microbiome (Camb). 2024; 4:e10.

PMID: 39295900 PMC: 11406377. DOI: 10.1017/gmb.2023.7.

Inflammasome activity regulation by PUFA metabolites.

Atalay Ekiner S, Gegotek A, Skrzydlewska E Front Immunol. 2024; 15:1452749.

PMID: 39290706 PMC: 11405227. DOI: 10.3389/fimmu.2024.1452749.

References

Seidner D, Lashner B, Brzezinski A, Banks P, Goldblum J, Fiocchi C . An oral supplement enriched with fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis: a randomized, controlled trial. Clin Gastroenterol Hepatol. 2005; 3(4):358-69. DOI: 10.1016/s1542-3565(04)00672-x. View

Ichihara H, Hino M, Ueoka R, Matsumoto Y . Therapeutic effects of cationic hybrid liposomes on the hepatic metastasis of colon carcinoma along with apoptosis in vivo. Biol Pharm Bull. 2014; 37(3):498-503. DOI: 10.1248/bpb.b13-00764. View

Galano J, Lee J, Gladine C, Comte B, Le Guennec J, Oger C . Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and α-linolenic acids; bioactivities and potential use as biomarkers. Biochim Biophys Acta. 2014; 1851(4):446-55. DOI: 10.1016/j.bbalip.2014.11.004. View

Serhan C . Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014; 510(7503):92-101. PMC: 4263681. DOI: 10.1038/nature13479. View

Collett E, Davidson L, Fan Y, Lupton J, Chapkin R . n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. Am J Physiol Cell Physiol. 2001; 280(5):C1066-75. DOI: 10.1152/ajpcell.2001.280.5.C1066. View

Alhouayek M, Muccioli G . The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. Trends Mol Med. 2012; 18(10):615-25. DOI: 10.1016/j.molmed.2012.07.009. View

Shen X, Zhou J, Dong J, Ding W, Wu J . Dietary intake of n-3 fatty acids and colorectal cancer risk: a meta-analysis of data from 489 000 individuals. Br J Nutr. 2012; 108(9):1550-6. DOI: 10.1017/S0007114512003546. View

Viladomiu M, Hontecillas R, Yuan L, Lu P, Bassaganya-Riera J . Nutritional protective mechanisms against gut inflammation. J Nutr Biochem. 2013; 24(6):929-39. PMC: 3730123. DOI: 10.1016/j.jnutbio.2013.01.006. View

Chassaing B, Aitken J, Malleshappa M, Vijay-Kumar M . Dextran sulfate sodium (DSS)-induced colitis in mice. Curr Protoc Immunol. 2014; 104:15.25.1-15.25.14. PMC: 3980572. DOI: 10.1002/0471142735.im1525s104. View

10.

Chey W, Maneerattaporn M, Saad R . Pharmacologic and complementary and alternative medicine therapies for irritable bowel syndrome. Gut Liver. 2011; 5(3):253-66. PMC: 3166664. DOI: 10.5009/gnl.2011.5.3.253. View

11.

Gomolka B, Siegert E, Blossey K, Schunck W, Rothe M, Weylandt K . Analysis of omega-3 and omega-6 fatty acid-derived lipid metabolite formation in human and mouse blood samples. Prostaglandins Other Lipid Mediat. 2011; 94(3-4):81-7. DOI: 10.1016/j.prostaglandins.2010.12.006. View

12.

Gonzalez-Rodriguez L, Aparicio A, Lopez-Sobaler A, Ortega R . Omega 3 and omega 6 fatty acids intake and dietary sources in a representative sample of Spanish adults. Int J Vitam Nutr Res. 2013; 83(1):36-47. DOI: 10.1024/0300-9831/a000143. View

13.

Park J, Kwon S, Han Y, Hahm K, Kim E . Omega-3 polyunsaturated Fatty acids as potential chemopreventive agent for gastrointestinal cancer. J Cancer Prev. 2014; 18(3):201-8. PMC: 4189468. DOI: 10.15430/jcp.2013.18.3.201. View

14.

Ye Y, Pang Z, Chen W, Ju S, Zhou C . The epidemiology and risk factors of inflammatory bowel disease. Int J Clin Exp Med. 2016; 8(12):22529-42. PMC: 4730025. View

15.

Maderna P, Godson C . Lipoxins: resolutionary road. Br J Pharmacol. 2009; 158(4):947-59. PMC: 2785518. DOI: 10.1111/j.1476-5381.2009.00386.x. View

16.

Khanna R, Feagan B . Safety of infliximab for the treatment of inflammatory bowel disease: current understanding of the potential for serious adverse events. Expert Opin Drug Saf. 2015; 14(6):987-97. DOI: 10.1517/14740338.2015.1029915. View

17.

Crosara Teixeira M, Braghiroli M, Sabbaga J, Hoff P . Primary prevention of colorectal cancer: myth or reality?. World J Gastroenterol. 2014; 20(41):15060-9. PMC: 4223239. DOI: 10.3748/wjg.v20.i41.15060. View

18.

Jia H, Zhang P, Liu Y, Jiang C, Zhu X, Tian Y . Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer. World J Gastroenterol. 2016; 22(8):2524-32. PMC: 4768198. DOI: 10.3748/wjg.v22.i8.2524. View

19.

Salaga M, Blomster L, Piechota-Polanczyk A, Zielinska M, Jacenik D, Cygankiewicz A . Encenicline, an α7 Nicotinic Acetylcholine Receptor Partial Agonist, Reduces Immune Cell Infiltration in the Colon and Improves Experimental Colitis in Mice. J Pharmacol Exp Ther. 2015; 356(1):157-69. DOI: 10.1124/jpet.115.228205. View

20.

Vasudevan A, Yu Y, Banerjee S, Woods J, Farhana L, G Rajendra S . Omega-3 fatty acid is a potential preventive agent for recurrent colon cancer. Cancer Prev Res (Phila). 2014; 7(11):1138-48. PMC: 4221533. DOI: 10.1158/1940-6207.CAPR-14-0177. View