Novel Activity of an Anti-inflammatory Cytokine: IL-10 Prevents TNFalpha-induced Resistance to IGF-I in Myoblasts

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 2007 Jun 19

PMID 17572510

Citations 18

Authors

Klemen Strle

Robert H McCusker

Lynn Tran

Alexandra King

Rodney W Johnson

Gregory G Freund

Robert Dantzer

Keith W Kelley

Affiliations

Soon will be listed here.

Abstract

IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFalpha-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFalpha to inhibit IGF-I-induced myogenin. This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFalpha-induced IL-6 synthesis or ERK1/2 phosphorylation. Instead, IL-10 acts to prevent TNFalpha-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFalpha-induced resistance to IGF-I.

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