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Exon Arrays Provide Accurate Assessments of Gene Expression

Overview
Journal Genome Biol
Specialties Biology
Genetics
Date 2007 May 17
PMID 17504534
Citations 71
Authors
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Abstract

We have developed a strategy for estimating gene expression on Affymetrix Exon arrays. The method includes a probe-specific background correction and a probe selection strategy in which a subset of probes with highly correlated intensities across multiple samples are chosen to summarize gene expression. Our results demonstrate that the proposed background model offers improvements over the default Affymetrix background correction and that Exon arrays may provide more accurate measurements of gene expression than traditional 3' arrays.

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