Progesterone and Oestradiol Increase Cytosolic Ca2+ in Single Rat Hepatocytes

Overview

Journal Biochem J

Specialty Biochemistry

Date 1991 Nov 15

PMID 1741753

Citations 6

Authors

M J Sancho

P H Cobbold

Affiliations

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Abstract

Progesterone (300-400 microM) and oestradiol (25-200 microM) induce a prompt rise in the cytosolic free Ca2+ concentration (free Ca) in single rat hepatocytes, but testosterone, cortisol and dexamethasone do not. These increases are dependent on the presence of extracellular Ca2+. Both progesterone and oestradiol block phenylephrine-induced free Ca oscillations. These data suggest a certain specificity of the response of free Ca to steroids and may explain some of the non-genomic effects of these steroids on hepatocytes.

Citing Articles

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Rapid non-genomic activation of cytosolic cyclic AMP-dependent protein kinase activity and [Ca(2+)](i) by 17beta-oestradiol in female rat distal colon.

Doolan C, Condliffe S, Harvey B Br J Pharmacol. 2000; 129(7):1375-86.

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References

Thomas P, Meizel S . Phosphatidylinositol 4,5-bisphosphate hydrolysis in human sperm stimulated with follicular fluid or progesterone is dependent upon Ca2+ influx. Biochem J. 1989; 264(2):539-46. PMC: 1133613. DOI: 10.1042/bj2640539. View

Cobbold P, Dixon C . The hepatocyte calcium oscillator. Cell Calcium. 1991; 12(2-3):87-95. DOI: 10.1016/0143-4160(91)90011-3. View

Sancho M, Gomez-Munoz A, Trueba M, Marino A . Glycogen phosphorylase activation by progesterone in liver. Exp Clin Endocrinol. 1988; 92(2):154-60. DOI: 10.1055/s-0029-1210795. View

Sancho M, Trueba M, MACARULLA J . An early effect of estradiol at hepatic level, previous to its protein synthesis activation. Int J Biochem. 1987; 19(1):93-6. DOI: 10.1016/0020-711x(87)90129-7. View

Sancho M, Egana M, Trueba M, Marino A, MACARULLA J . Two independent effects of cortisol on chicken liver. Exp Clin Endocrinol. 1986; 88(2):249-55. DOI: 10.1055/s-0029-1210604. View

Deliconstantinos G . Structure activity relationship of cholesterol and steroid hormones with respect to their effects on the Ca2+-stimulated ATPase and lipid fluidity of synaptosomal plasma membranes from dog and rabbit brain. Comp Biochem Physiol B. 1988; 89(3):585-94. DOI: 10.1016/0305-0491(88)90178-2. View

Baran D, Milne M . 1,25 Dihydroxyvitamin D increases hepatocyte cytosolic calcium levels. A potential regulator of vitamin D-25-hydroxylase. J Clin Invest. 1986; 77(5):1622-6. PMC: 424566. DOI: 10.1172/JCI112478. View

Berridge M, Irvine R . Inositol phosphates and cell signalling. Nature. 1989; 341(6239):197-205. DOI: 10.1038/341197a0. View

Morishita S, Saito T . Effect of progesterone on the stimulation of phosphatidylinositol turnover by epinephrine in guinea pig ductus deferens. Jpn J Pharmacol. 1989; 49(1):95-9. DOI: 10.1254/jjp.49.95. View

10.

OSullivan A, Cheek T, Moreton R, Berridge M, Burgoyne R . Localization and heterogeneity of agonist-induced changes in cytosolic calcium concentration in single bovine adrenal chromaffin cells from video imaging of fura-2. EMBO J. 1989; 8(2):401-11. PMC: 400820. DOI: 10.1002/j.1460-2075.1989.tb03391.x. View

11.

Diez A, Sancho M, Egana M, Trueba M, Marino A, MACARULLA J . An interaction of testosterone with cell membranes. Horm Metab Res. 1984; 16(9):475-7. DOI: 10.1055/s-2007-1014823. View

12.

Eisenfeld A, Aten R . Estrogen receptors and androgen receptors in the mammalian liver. J Steroid Biochem. 1987; 27(4-6):1109-18. DOI: 10.1016/0022-4731(87)90197-x. View

13.

Grove R, Korach K . Estrogen stimulation of phosphatidylinositol metabolism in mouse uterine tissue. Endocrinology. 1987; 121(3):1083-8. DOI: 10.1210/endo-121-3-1083. View

14.

Dixon C, Woods N, Cuthbertson K, Cobbold P . Inhibitors of protein kinase C prolong the falling phase of each free-calcium transient in a hormone-stimulated hepatocyte. Biochem J. 1990; 268(3):627-32. PMC: 1131485. DOI: 10.1042/bj2680627. View

15.

Blackmore P, Beebe S, Danforth D, Alexander N . Progesterone and 17 alpha-hydroxyprogesterone. Novel stimulators of calcium influx in human sperm. J Biol Chem. 1990; 265(3):1376-80. View

16.

Dixon C, Woods N, Cuthbertson K, Cobbold P . Evidence for two Ca2(+)-mobilizing purinoceptors on rat hepatocytes. Biochem J. 1990; 269(2):499-502. PMC: 1131604. DOI: 10.1042/bj2690499. View

17.

Woods N, Dixon C, Cuthbertson K, Cobbold P . Modulation of free Ca oscillations in single hepatocytes by changes in extracellular K+, Na+ and Ca2+. Cell Calcium. 1990; 11(5):353-60. DOI: 10.1016/0143-4160(90)90038-v. View

18.

Duval D, Durant S, Homo-Delarche F . Non-genomic effects of steroids. Interactions of steroid molecules with membrane structures and functions. Biochim Biophys Acta. 1983; 737(3-4):409-42. DOI: 10.1016/0304-4157(83)90008-4. View

19.

Egana M, Sancho M, MACARULLA J . An early effect of cortisol, previous to its glycogenogenic action. Horm Metab Res. 1981; 13(11):609-11. DOI: 10.1055/s-2007-1019351. View

20.

Rasmussen H, Matsumoto T, Fontaine O, GOODMAN D . Role of changes in membrane lipid structure in the action of 1,25-dihydroxyvitamin D3. Fed Proc. 1982; 41(1):72-7. View