Public and Private Mechanisms of Life Extension in Caenorhabditis Elegans

Overview

Journal Mol Genet Genomics

Specialty Genetics

Date 2007 Mar 17

PMID 17364197

Citations 12

Authors

Koen Houthoofd

Jacques R Vanfleteren

Affiliations

Soon will be listed here.

Abstract

Model organisms have been widely used to study the ageing phenomenon in order to learn about human ageing. Although the phylogenetic diversity between vertebrates and some of the most commonly used model systems could hardly be greater, several mechanisms of life extension are public (common characteristic in divergent species) and likely share a common ancestry. Dietary restriction, reduced IGF-signaling and, seemingly, reduced ROS-induced damage are the best known mechanisms for extending longevity in a variety of organisms. In this review, we summarize the knowledge of ageing in the nematode Caenorhabditis elegans and compare the mechanisms of life extension with knowledge from other model organisms.

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References

Van Voorhies W . Is life span extension in single gene long-lived Caenorhabditis elegans mutants due to hypometabolism?. Exp Gerontol. 2003; 38(6):615-8. DOI: 10.1016/s0531-5565(03)00070-6. View

Stenmark P, Grunler J, Mattsson J, SINDELAR P, Nordlund P, Berthold D . A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis. J Biol Chem. 2001; 276(36):33297-300. DOI: 10.1074/jbc.C100346200. View

Murphy C, McCarroll S, Bargmann C, Fraser A, Kamath R, Ahringer J . Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 2003; 424(6946):277-83. DOI: 10.1038/nature01789. View

Himmelhoch S, Kisiel M, Zuckerman B . Caenorhabditis briggsae: electron microscope analysis of changes in negative surface charge density of the outer cuticular membrane. Exp Parasitol. 1977; 41(1):118-23. DOI: 10.1016/0014-4894(77)90137-0. View

Henderson S, Bonafe M, Johnson T . daf-16 protects the nematode Caenorhabditis elegans during food deprivation. J Gerontol A Biol Sci Med Sci. 2006; 61(5):444-60. DOI: 10.1093/gerona/61.5.444. View

Kisiel M, Castillo J, Zuckerman L, Zuckerman B . Studies on ageing in Turbatrix aceti. Mech Ageing Dev. 1975; 4(1):81-8. DOI: 10.1016/0047-6374(75)90009-3. View

van Heemst D, Beekman M, Mooijaart S, Heijmans B, Brandt B, Zwaan B . Reduced insulin/IGF-1 signalling and human longevity. Aging Cell. 2005; 4(2):79-85. DOI: 10.1111/j.1474-9728.2005.00148.x. View

Larsen P . Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1993; 90(19):8905-9. PMC: 47469. DOI: 10.1073/pnas.90.19.8905. View

Adams T, Epa V, Garrett T, Ward C . Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci. 2000; 57(7):1050-93. PMC: 11146944. DOI: 10.1007/PL00000744. View

10.

Yashin A, Cypser J, Johnson T, Michalski A, Boyko S, Novoseltsev V . Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans. Mech Ageing Dev. 2001; 122(13):1477-95. DOI: 10.1016/s0047-6374(01)00273-1. View

11.

Asaumi S, Kuroyanagi H, Seki N, Shirasawa T . Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human. Genomics. 1999; 58(3):293-301. DOI: 10.1006/geno.1999.5838. View

12.

van der Horst A, Tertoolen L, de Vries-Smits L, Frye R, Medema R, Burgering B . FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem. 2004; 279(28):28873-9. DOI: 10.1074/jbc.M401138200. View

13.

Davis Jr B, Anderson G, Dusenbery D . Total luminescence spectroscopy of fluorescence changes during aging in Caenorhabditis elegans. Biochemistry. 1982; 21(17):4089-95. DOI: 10.1021/bi00260a027. View

14.

Alcedo J, Kenyon C . Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron. 2004; 41(1):45-55. DOI: 10.1016/s0896-6273(03)00816-x. View

15.

Bokov A, Chaudhuri A, Richardson A . The role of oxidative damage and stress in aging. Mech Ageing Dev. 2004; 125(10-11):811-26. DOI: 10.1016/j.mad.2004.07.009. View

16.

Rottiers V, Motola D, Gerisch B, Cummins C, Nishiwaki K, Mangelsdorf D . Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Dev Cell. 2006; 10(4):473-82. DOI: 10.1016/j.devcel.2006.02.008. View

17.

Klass M . A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech Ageing Dev. 1983; 22(3-4):279-86. DOI: 10.1016/0047-6374(83)90082-9. View

18.

Oh S, Mukhopadhyay A, Dixit B, Raha T, Green M, Tissenbaum H . Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat Genet. 2005; 38(2):251-7. DOI: 10.1038/ng1723. View

19.

Motola D, Cummins C, Rottiers V, Sharma K, Li T, Li Y . Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell. 2006; 124(6):1209-23. DOI: 10.1016/j.cell.2006.01.037. View

20.

Johnson T . Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1987; 84(11):3777-81. PMC: 304959. DOI: 10.1073/pnas.84.11.3777. View