Beta-Catenin/TCF/LEF Regulate Expression of the Short Form Human Cripto-1

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 2007 Feb 13

PMID 17291450

Citations 20

Authors

Shin Hamada

Kazuhide Watanabe

Morihisa Hirota

Caterina Bianco

Luigi Strizzi

Mario Mancino

Monica Gonzales

David S Salomon

Affiliations

Soon will be listed here.

Abstract

The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-catenin/TCF signaling pathway, also express CR-1. Expression of a short form of CR-1 mRNA in colon carcinoma and hepatoma cell lines suggests that there may be differential regulation of CR-1 expression by the canonical Wnt signaling pathway in colon cancer as well as hepatoma cell lines. The present study demonstrates a direct transcriptional regulation of the short form CR-1 expression by the canonical Wnt signaling pathway through an intronic-exonic enhancer element, containing three tandem TCF/LEF binding sites within the CR-1 gene.

Citing Articles

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Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways.

Liu Y, Li Y, Huang S, Li Y, Xia J, Jia J Aging (Albany NY). 2021; 13(17):21155-21190.

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A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles.

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Effects of Estrogen and Estrogen Receptors on Transcriptomes of HepG2 Cells: A Preliminary Study Using RNA Sequencing.

Shen M, Cao J, Shi H Int J Endocrinol. 2018; 2018:5789127.

PMID: 30510575 PMC: 6230429. DOI: 10.1155/2018/5789127.

Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway.

Lo R, Leung C, Chan K, Ho D, Wong C, Lee T Cell Death Differ. 2018; 25(8):1426-1441.

PMID: 29445127 PMC: 6113239. DOI: 10.1038/s41418-018-0059-x.

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