Role of Cripto-1 During Epithelial-to-mesenchymal Transition in Development and Cancer

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 2012 May 1

PMID 22542493

Citations 59

Authors

Maria C Rangel

Hideaki Karasawa

Nadia P Castro

Tadahiro Nagaoka

David S Salomon

Caterina Bianco

Affiliations

Soon will be listed here.

Abstract

Epithelial-to-mesenchymal transition (EMT) is a critical multistep process that converts epithelial cells to more motile and invasive mesenchymal cells, contributing to body patterning and morphogenesis during embryonic development. In addition, both epithelial plasticity and increased motility and invasiveness are essential for the branching morphogenesis that occurs during development of the mammary gland and during tumor formation, allowing cancer cells to escape from the primary tumor. Cripto-1, a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family, together with the transforming growth factor (TGF)-β family ligand Nodal, regulates both cell movement and EMT during embryonic development. During postnatal development, Cripto-1 regulates the branching morphogenesis of the mouse mammary gland and enhances both the invasive and migratory properties of mammary epithelial cells in vitro. Furthermore, transgenic mouse models have shown that Cripto-1 promotes the formation of mammary tumors that display properties of EMT, including the down-regulation of the cell surface adherens junctional protein E-cadherin and the up-regulation of mesenchymal markers, such as vimentin, N-cadherin, and Snail. Interestingly, Cripto-1 is enriched in a subpopulation of embryonal, melanoma, prostate, and pancreatic cancer cells that possess stem-like characteristics. Therefore, Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.

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References

Zhang C, Klymkowsky M . Unexpected functional redundancy between Twist and Slug (Snail2) and their feedback regulation of NF-kappaB via Nodal and Cerberus. Dev Biol. 2009; 331(2):340-9. PMC: 2747320. DOI: 10.1016/j.ydbio.2009.04.016. View

Li J, Zhou B . Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters. BMC Cancer. 2011; 11:49. PMC: 3040162. DOI: 10.1186/1471-2407-11-49. View

Jarde T, Dale T . Wnt signalling in murine postnatal mammary gland development. Acta Physiol (Oxf). 2011; 204(1):118-27. DOI: 10.1111/j.1748-1716.2011.02283.x. View

Miyoshi K, Shillingford J, Le Provost F, Gounari F, Bronson R, von Boehmer H . Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias. Proc Natl Acad Sci U S A. 2002; 99(1):219-24. PMC: 117542. DOI: 10.1073/pnas.012414099. View

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K . Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131(5):861-72. DOI: 10.1016/j.cell.2007.11.019. View

Lonardo E, Parish C, Ponticelli S, Marasco D, Ribeiro D, Ruvo M . A small synthetic cripto blocking Peptide improves neural induction, dopaminergic differentiation, and functional integration of mouse embryonic stem cells in a rat model of Parkinson's disease. Stem Cells. 2010; 28(8):1326-37. DOI: 10.1002/stem.458. View

Marikawa Y, Tamashiro D, Fujita T, Alarcon V . Dual roles of Oct4 in the maintenance of mouse P19 embryonal carcinoma cells: as negative regulator of Wnt/β-catenin signaling and competence provider for Brachyury induction. Stem Cells Dev. 2010; 20(4):621-33. PMC: 3112048. DOI: 10.1089/scd.2010.0209. View

Yoon H, Hong J, Shin W, Lee Y, Hong K, Lee J . The role of Cripto-1 in the tumorigenesis and progression of oral squamous cell carcinoma. Oral Oncol. 2011; 47(11):1023-31. DOI: 10.1016/j.oraloncology.2011.07.019. View

Chu J, Shen M . Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis. Dev Biol. 2010; 342(1):63-73. PMC: 2866749. DOI: 10.1016/j.ydbio.2010.03.009. View

10.

Sternlicht M . Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis. Breast Cancer Res. 2006; 8(1):201. PMC: 1413974. DOI: 10.1186/bcr1368. View

11.

Kelber J, Panopoulos A, Shani G, Booker E, Belmonte J, Vale W . Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. Oncogene. 2009; 28(24):2324-36. PMC: 2749668. DOI: 10.1038/onc.2009.97. View

12.

Mani S, Guo W, Liao M, Eaton E, Ayyanan A, Zhou A . The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008; 133(4):704-15. PMC: 2728032. DOI: 10.1016/j.cell.2008.03.027. View

13.

Azhar M, Brown K, Gard C, Chen H, Rajan S, Elliott D . Transforming growth factor Beta2 is required for valve remodeling during heart development. Dev Dyn. 2011; 240(9):2127-41. PMC: 3337781. DOI: 10.1002/dvdy.22702. View

14.

Adkins H, Bianco C, Schiffer S, Rayhorn P, Zafari M, Cheung A . Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo. J Clin Invest. 2003; 112(4):575-87. PMC: 171388. DOI: 10.1172/JCI17788. View

15.

Gray P, Shani G, Aung K, Kelber J, Vale W . Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signaling. Mol Cell Biol. 2006; 26(24):9268-78. PMC: 1698529. DOI: 10.1128/MCB.01168-06. View

16.

Teuliere J, Faraldo M, Deugnier M, Shtutman M, Ben-Zeev A, Thiery J . Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia. Development. 2004; 132(2):267-77. DOI: 10.1242/dev.01583. View

17.

Postovit L, Margaryan N, Seftor E, Kirschmann D, Lipavsky A, Wheaton W . Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc Natl Acad Sci U S A. 2008; 105(11):4329-34. PMC: 2393795. DOI: 10.1073/pnas.0800467105. View

18.

Casamassimi A, De Luca A, Agrawal S, Stromberg K, Salomon D, Normanno N . EGF-related antisense oligonucleotides inhibit the proliferation of human ovarian carcinoma cells. Ann Oncol. 2000; 11(3):319-25. DOI: 10.1023/a:1008350811639. View

19.

In Yook J, Li X, Ota I, Hu C, Kim H, Kim N . A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol. 2006; 8(12):1398-406. DOI: 10.1038/ncb1508. View

20.

Lawrence M, Margaryan N, Loessner D, Collins A, Kerr K, Turner M . Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells. Prostate. 2011; 71(11):1198-209. PMC: 3234312. DOI: 10.1002/pros.21335. View