Impact of Tiny MiRNAs on Cancers

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2007 Feb 6

PMID 17278213

Citations 33

Authors

Wei Liu

Sheng-Yong Mao

Wei-Yun Zhu

Affiliations

Soon will be listed here.

Abstract

miRNAs are a class of small, approximately 22nt, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. They play profound and pervasive roles in manipulating gene expression involved in cell development, proliferation and apoptosis in various eukaryotes, which, in theory, could provide an access to many human diseases in theory. Recent evidence demonstrates that aberrant miRNA expression is a hallmark of tumor development, revealing that miRNA genes could function as potential oncogenes and repressors in the human body. miRNAs can affect tumorigenesis mainly by interrupting the cell cycle at the cellular level and by interacting with signaling, oncogenes and with the response to environmental factors at the molecular level. The established miRNA expression signature could be a potent tool to diagnose and treat human cancers in the future.

Citing Articles

KLK10/LIPH/PARD6B/SLC52A3 are promising molecular biomarkers for the prognosis of pancreatic cancer through a ceRNA network.

Zhang M, Jiang L, Liu X, Liu F, Zhang H, Zhang Y Heliyon. 2024; 10(1):e24287.

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Harnessing Epigenetics for Breast Cancer Therapy: The Role of DNA Methylation, Histone Modifications, and MicroRNA.

Szczepanek J, Skorupa M, Jarkiewicz-Tretyn J, Cybulski C, Tretyn A Int J Mol Sci. 2023; 24(8).

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The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer.

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Long intergenic non-protein coding RNA 1094 (LINC01094) promotes the progression of breast cancer (BC) by regulating the microRNA-340-5p (miR-340-5p)/E2F transcription factor 3 (E2F3) axis.

Wu X, Kong C, Wu Y Bioengineered. 2021; 12(1):9046-9057.

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MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review.

Volovat S, Volovat C, Hordila I, Hordila D, Mirestean C, Miron O Front Oncol. 2020; 10:526850.

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