Control of Human Immunodeficiency Virus Type 1 is Associated with HLA-B*13 and Targeting of Multiple Gag-specific CD8+ T-cell Epitopes

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2007 Jan 26

PMID 17251285

Citations 90

Authors

Isobella Honeyborne

Andrew Prendergast

Florencia Pereyra

Alasdair Leslie

Hayley Crawford

Rebecca Payne

Shabashini Reddy

Karen Bishop

Eshia Moodley

Kriebashnie Nair

Mary van der Stok

Noel McCarthy

Christine M Rousseau

Marylyn Addo

James I Mullins

Christian Brander

Photini Kiepiela

Bruce D Walker

Philip J R Goulder

Affiliations

Soon will be listed here.

Abstract

To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8+ response that is associated with the control of viremia. These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.

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