Effect of Antibiotics on Staphylococcus Aureus Producing Panton-Valentine Leukocidin

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2007 Jan 24

PMID 17242137

Citations 67

Authors

Oana Dumitrescu

Sandrine Boisset

Cedric Badiou

Michele Bes

Yvonne Benito

Marie-Elisabeth Reverdy

Francois Vandenesch

Jerome Etienne

Gerard Lina

Affiliations

Soon will be listed here.

Abstract

We examined the capacity of Staphylococcus aureus strains to release Panton-Valentine leukocidin (PVL) in the presence of antibiotics. No PVL was detected when S. aureus was incubated at inhibitory concentrations, while subinhibitory concentrations of oxacillin enhanced the PVL level; clindamycin, linezolid, and fusidic acid were inhibitory; and vancomycin had roughly no effect.

Citing Articles

Severe Panton-Valentine-Leukocidin-Positive Infections in Pediatric Age: A Case Report and a Literature Review.

Garbo V, Venuti L, Boncori G, Albano C, Condemi A, Natoli G Antibiotics (Basel). 2025; 13(12.

PMID: 39766583 PMC: 11672633. DOI: 10.3390/antibiotics13121192.

Ecthyma Gangrenosum Secondary to Panton-Valentine Leukocidin-Secreting Staphylococcus aureus in an Immunocompetent Patient.

Blanchet F, Delannoy M, Forasassi C, Fontaine J, Carre F, Chopin D Dermatol Pract Concept. 2024; 14(4).

PMID: 39652931 PMC: 11619933. DOI: 10.5826/dpc.1404a233.

Infective endocarditis due to nasal septal perforation during home oxygen therapy.

Shinfuku K, Takasaka N, Ohashi R, Fukuda T, Takatsuka M, Sato R Respirol Case Rep. 2024; 12(10):e70038.

PMID: 39376798 PMC: 11456808. DOI: 10.1002/rcr2.70038.

A case of community-acquired Panton-Valentine leukocidin-positive methicillin-resistant (MRSA) necrotizing pneumonia successfully treated with two anti-MRSA drugs.

Shiiba R, Sano M, Kogure Y, Murao H, Takigawa Y, Torii A Respir Med Case Rep. 2024; 49:102023.

PMID: 38681212 PMC: 11046217. DOI: 10.1016/j.rmcr.2024.102023.

Staphylococcus aureus Pneumonia in Can Tho, Vietnam: Clinical Characteristics, Antimicrobial Resistance Profile and Risk Factors of Mortality.

Vo-Pham-Minh T, Tran-Cong D, Phan-Viet H, Dinh-Chi T, Nguyen-Thi-Hong T, Cao-Thi-My T Pulm Ther. 2024; 10(2):193-205.

PMID: 38446335 PMC: 11282013. DOI: 10.1007/s41030-024-00254-2.

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