A Case of Community-acquired Panton-Valentine Leukocidin-positive Methicillin-resistant (MRSA) Necrotizing Pneumonia Successfully Treated with Two Anti-MRSA Drugs

Overview

Journal Respir Med Case Rep

Date 2024 Apr 29

PMID 38681212

Authors

Ritsuya Shiiba

Masahiro Sano

Yoshihito Kogure

Hiroto Murao

Yuki Takigawa

Atsushi Torii

Arisa Yamada

Yuka Shinohara

Hideyuki Niwa

Chiyoe Kitagawa

Masahide Oki

Affiliations

Soon will be listed here.

Abstract

A 22-year-old Vietnamese man was referred to our hospital owing to cough, dyspnea, and difficulty moving. The patient was diagnosed with community-acquired Panton-Valentine leukocidin-positive methicillin-resistant (MRSA) bacteremia and necrotizing pneumonia. Treatment involved vancomycin (VCM) and meropenem, and the MRSA bacteremia improved. However, lung tissue destruction progressed. Therefore, linezolid was added to the VCM regimen, and this intervention led to the patient's recovery, and he was discharged from the hospital. Here, we report a case in which the patient was treated with a combination of two anti-MRSA drugs and was cured.

References

Harigaya Y, Bulitta J, Forrest A, Sakoulas G, Lesse A, Mylotte J . Pharmacodynamics of vancomycin at simulated epithelial lining fluid concentrations against methicillin-resistant Staphylococcus aureus (MRSA): implications for dosing in MRSA pneumonia. Antimicrob Agents Chemother. 2009; 53(9):3894-901. PMC: 2737835. DOI: 10.1128/AAC.01585-08. View

Boyle-Vavra S, Daum R . Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin. Lab Invest. 2006; 87(1):3-9. DOI: 10.1038/labinvest.3700501. View

Shinabarger D, Marotti K, Murray R, Lin A, Melchior E, Swaney S . Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions. Antimicrob Agents Chemother. 1997; 41(10):2132-6. PMC: 164082. DOI: 10.1128/AAC.41.10.2132. View

Yamaguchi T, Nakamura I, Sato T, Ono D, Sato A, Sonoda S . Changes in the Genotypic Characteristics of Community-Acquired Methicillin-Resistant Staphylococcus aureus Collected in 244 Medical Facilities in Japan between 2010 and 2018: a Nationwide Surveillance. Microbiol Spectr. 2022; 10(4):e0227221. PMC: 9431082. DOI: 10.1128/spectrum.02272-21. View

Aung M, Urushibara N, Kawaguchiya M, Hirose M, Ito M, Habadera S . Clonal diversity of methicillin-resistant Staphylococcus aureus (MRSA) from bloodstream infections in northern Japan: Identification of spermidine N-acetyltransferase gene (speG) in staphylococcal cassette chromosomes (SCCs) associated with type II.... J Glob Antimicrob Resist. 2020; 24:207-214. DOI: 10.1016/j.jgar.2020.12.008. View

Brown N, Goodman A, Horner C, Jenkins A, Brown E . Treatment of methicillin-resistant (MRSA): updated guidelines from the UK. JAC Antimicrob Resist. 2021; 3(1):dlaa114. PMC: 8210269. DOI: 10.1093/jacamr/dlaa114. View

He H, Wunderink R . Staphylococcus aureus Pneumonia in the Community. Semin Respir Crit Care Med. 2020; 41(4):470-479. DOI: 10.1055/s-0040-1709992. View

Mulazimoglu L, Drenning S, Yu V . In vitro activities of two novel oxazolidinones (U100592 and U100766), a new fluoroquinolone (trovafloxacin), and dalfopristin-quinupristin against Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother. 1996; 40(10):2428-30. PMC: 163549. DOI: 10.1128/AAC.40.10.2428. View

Ahmad N, Yean Yean C, Foo P, Safiee A, Hassan S . Prevalence and association of Panton-Valentine Leukocidin gene with the risk of sepsis in patients infected with Methicillin Resistant Staphylococcus aureus. J Infect Public Health. 2020; 13(10):1508-1512. DOI: 10.1016/j.jiph.2020.06.018. View

10.

Jacqueline C, Caillon J, Le Mabecque V, Miegeville A, Donnio P, Bugnon D . In vitro activity of linezolid alone and in combination with gentamicin, vancomycin or rifampicin against methicillin-resistant Staphylococcus aureus by time-kill curve methods. J Antimicrob Chemother. 2003; 51(4):857-64. DOI: 10.1093/jac/dkg160. View

11.

Genestier A, Michallet M, Prevost G, Bellot G, Chalabreysse L, Peyrol S . Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils. J Clin Invest. 2005; 115(11):3117-27. PMC: 1265849. DOI: 10.1172/JCI22684. View

12.

Dumitrescu O, Boisset S, Badiou C, Bes M, Benito Y, Reverdy M . Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin. Antimicrob Agents Chemother. 2007; 51(4):1515-9. PMC: 1855455. DOI: 10.1128/AAC.01201-06. View

13.

Takadama S, Nakaminami H, Sato A, Shoshi M, Fujii T, Noguchi N . Dissemination of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus USA300 clone in multiple hospitals in Tokyo, Japan. Clin Microbiol Infect. 2018; 24(11):1211.e1-1211.e7. DOI: 10.1016/j.cmi.2018.02.012. View

14.

Moller J, Larsen A, Ostergaard C, Moller C, Assenholm Kristensen M, Larsen J . International travel as source of a hospital outbreak with an unusual meticillin-resistant clonal complex 398, Denmark, 2016. Euro Surveill. 2019; 24(42). PMC: 6807253. DOI: 10.2807/1560-7917.ES.2019.24.42.1800680. View

15.

Gillet Y, Issartel B, Vanhems P, Fournet J, Lina G, Bes M . Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet. 2002; 359(9308):753-9. DOI: 10.1016/S0140-6736(02)07877-7. View

16.

Nakaminami H, Hirai Y, Nishimura H, Takadama S, Noguchi N . Arthritis Caused by MRSA CC398 in a Patient without Animal Contact, Japan. Emerg Infect Dis. 2020; 26(4):795-797. PMC: 7101128. DOI: 10.3201/eid2604.190376. View

17.

Singh S, Bacon 3rd A, Young D, Couch K . In vitro 24-hour time-kill studies of vancomycin and linezolid in combination versus methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2009; 53(10):4495-7. PMC: 2764166. DOI: 10.1128/AAC.00237-09. View