Dynamic Roles for G4 DNA in the Biology of Eukaryotic Cells

Overview

Journal Nat Struct Mol Biol

Specialties Cell Biology
Molecular Biology

Date 2006 Dec 6

PMID 17146462

Citations 191

Authors

Nancy Maizels

Affiliations

Soon will be listed here.

Abstract

Recent advances have made a persuasive case for the existence of G4 DNA in living cells, but what--if any--are its functions? Experiments have established how G4 DNA may contribute to the biology of eukaryotic cells, and genomic analysis has identified new ways in which the potential to form G4 DNA may influence gene regulation and genomic stability. This Perspective highlights those advances and identifies some key open questions.

Citing Articles

Long G4-rich enhancers target promoters via a G4 DNA-based mechanism.

DeMeis J, Roberts J, Delcher H, Godang N, Coley A, Brown C Nucleic Acids Res. 2024; 53(2.

PMID: 39658038 PMC: 11754661. DOI: 10.1093/nar/gkae1180.

Mutations at Exon 4 Associated with T Cell Acute Lymphoblastic Leukemia Are Facilitated by AID and Formation of Non-B DNA Conformations.

Roy U, Sharma A, Sharma S, Dahal S, Kumari N, Desai S Mol Cell Biol. 2024; 44(12):590-606.

PMID: 39511874 PMC: 11583620. DOI: 10.1080/10985549.2024.2419661.

Benzimidazole-based small molecules as anticancer agents targeting telomeric G-quadruplex and inhibiting telomerase enzyme.

Elango H, Nath Das R, Saha A Future Med Chem. 2024; 16(19):2043-2067.

PMID: 39316718 PMC: 11485724. DOI: 10.1080/17568919.2024.2400982.

Introns and Their Therapeutic Applications in Biomedical Researches.

Haddad-Mashadrizeh A, Mirahmadi M, Taghavizadeh Yazdi M, Gholampour-Faroji N, Bahrami A, Zomorodipour A Iran J Biotechnol. 2024; 21(4):e3316.

PMID: 38269198 PMC: 10804063. DOI: 10.30498/ijb.2023.334488.3316.

QUFIND: tool for comparative prediction and mining of G4 quadruplexes overlapping with CpG islands.

Kaur B, Sharma P, Arora P, Sood V Front Genet. 2023; 14:1265808.

PMID: 37953924 PMC: 10634401. DOI: 10.3389/fgene.2023.1265808.