Benzimidazole-based Small Molecules As Anticancer Agents Targeting Telomeric G-quadruplex and Inhibiting Telomerase Enzyme

Overview

Journal Future Med Chem

Specialties Chemistry
Pharmacy

Date 2024 Sep 24

PMID 39316718

Authors

Hemanathan Elango

Rabindra Nath Das

Abhijit Saha

Affiliations

Soon will be listed here.

Abstract

Telomeres, crucial for chromosomal integrity, have been related to aging and cancer formation, mainly through regulating G-quadruplex structures. G-quadruplexes are structural motifs that can arise as secondary structures of nucleic acids, especially in guanine-rich DNA and RNA regions. Targeting these structures by small compounds shows promise in the selective suppression of cell growth, opening up novel possibilities for anticancer treatment. A comprehensive investigation of the many structural forms of G-quadruplex ligands is required to create ground-breaking anticancer drugs. Recent research into using specific benzimidazole molecules in stabilizing telomeric DNA into G-quadruplex structures has highlighted their ability to influence oncogene expression and demonstrate antiproliferative characteristics against cancer cells. This review describes the benzimidazole derivative, designed to enhance the stability of the G-quadruplex structure DNA to suppress the activity of telomerase enzyme, exhibiting promising potential for anticancer therapy.

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